caa a22 4500 606176004 CHVBK 20210128100745.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00018-014-1755-4 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1755-4 Beta cell connectivity in pancreatic islets: a type 2 diabetes target? [Elektronische Daten] [Guy Rutter, David Hodson] Beta cell connectivity describes the phenomenon whereby the islet context improves insulin secretion by providing a three-dimensional platform for intercellular signaling processes. Thus, the precise flow of information through homotypically interconnected beta cells leads to the large-scale organization of hormone release activities, influencing cell responses to glucose and other secretagogues. Although a phenomenon whose importance has arguably been underappreciated in islet biology until recently, a growing number of studies suggest that such cell-cell communication is a fundamental property of this micro-organ. Hence, connectivity may plausibly be targeted by both environmental and genetic factors in type 2 diabetes mellitus (T2DM) to perturb normal beta cell function and insulin release. Here, we review the mechanisms that contribute to beta cell connectivity, discuss how these may fail during T2DM, and examine approaches to restore insulin secretion by boosting cell communication. Springer Basel, 2014 Mouse nationallicence Human nationallicence Signaling nationallicence Insulin nationallicence Diabetes nationallicence Imaging nationallicence Network nationallicence AC : Adenyl cyclase nationallicence ACh : Acetylcholine nationallicence ADP : Adenosine diphosphate nationallicence ATP : Adenosine triphosphate nationallicence cAMP : Cyclic adenosine monophosphate nationallicence Cx36 : Connexin 36 nationallicence Epac : Exchange protein activated by cAMP nationallicence fMCI : Functional multicellular calcium imaging nationallicence GABA : Gamma aminobutyric acid nationallicence GIP : Glucose-dependent insulinotropic polypeptide nationallicence GJ : Gap junction nationallicence GLP-1 : Glucagon-like peptide-1 nationallicence GWAS : Genome-wide association studies nationallicence GPCR : G protein-coupled receptor nationallicence KATP : ATP-sensitive K+ channel nationallicence SST : Somatostatin nationallicence SNP : Single nucleotide polymorphism nationallicence T2DM : Type 2 diabetes mellitus nationallicence VDCC : Voltage-dependent Ca2+-channel nationallicence Rutter Guy Section of Cell Biology, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK aut Hodson David Section of Cell Biology, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK aut Cellular and Molecular Life Sciences Springer International Publishing 72/3(2015-02-01), 453-467 1420-682X 72:3<453 2015 72 18 https://doi.org/10.1007/s00018-014-1755-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1755-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rutter Guy Section of Cell Biology, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK aut NATIONALLICENCE 700 1- Hodson David Section of Cell Biology, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer International Publishing 72/3(2015-02-01), 453-467 1420-682X 72:3<453 2015 72 18