caa a22 4500 606176039 CHVBK 20210128100745.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00018-015-1846-x doi (NATIONALLICENCE)springer-10.1007/s00018-015-1846-x The inflammatory microenvironment in MDS [Elektronische Daten] [Lili Yang, Yaqin Qian, Erika Eksioglu, Pearlie Epling-Burnette, Sheng Wei] Myelodysplastic syndromes (MDS) are a collection of pre-malignancies characterized by impaired proliferation and differentiation of hematopoietic stem cells and a tendency to evolve into leukemia. Among MDS's pathogenic mechanisms are genetic, epigenetic, apoptotic, differentiation, and cytokine milieu abnormalities. Inflammatory changes are a prominent morphologic feature in some cases, with increased populations of plasma cells, mast cells, and lymphocytes in bone marrow aspirates. Accumulating evidence suggests that the bone marrow microenvironment contributes to MDS disease pathology, with microenvironment alterations and abnormality preceding, and facilitating clonal evolution in MDS patients. In this review, we focus on the inflammatory changes involved in the pathology of MDS, with an emphasis on immune dysfunction, stromal microenvironment, and cytokine imbalance in the microenvironment as well as activation of innate immune signaling in MDS patients. A better understanding of the mechanism of MDS pathophysiology will be beneficial to the development of molecular-targeted therapies in the future. Springer Basel, 2015 Myelodysplastic syndromes (MDS) nationallicence Inflammation nationallicence Myeloid-derived suppressor cells (MDSC) nationallicence Microenvironment nationallicence Stromal cells nationallicence Immunosuppression nationallicence Innate immunity nationallicence Yang Lili Department of Immunology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China aut Qian Yaqin Department of Immunology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China aut Eksioglu Erika Immunology Program at the H Lee Moffitt Cancer Center, 12902 Magnolia Dr., 33612, Tampa, FL, USA aut Epling-Burnette Pearlie Immunology Program at the H Lee Moffitt Cancer Center, 12902 Magnolia Dr., 33612, Tampa, FL, USA aut Wei Sheng Department of Immunology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China aut Cellular and Molecular Life Sciences Springer Basel 72/10(2015-05-01), 1959-1966 1420-682X 72:10<1959 2015 72 18 https://doi.org/10.1007/s00018-015-1846-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1846-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Lili Department of Immunology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China aut NATIONALLICENCE 700 1- Qian Yaqin Department of Immunology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China aut NATIONALLICENCE 700 1- Eksioglu Erika Immunology Program at the H Lee Moffitt Cancer Center, 12902 Magnolia Dr., 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Epling-Burnette Pearlie Immunology Program at the H Lee Moffitt Cancer Center, 12902 Magnolia Dr., 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Wei Sheng Department of Immunology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/10(2015-05-01), 1959-1966 1420-682X 72:10<1959 2015 72 18