caa a22 4500 606176047 CHVBK 20210128100745.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00018-014-1811-0 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1811-0 Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles [Elektronische Daten] [Nao Nishida-Aoki, Takahiro Ochiya] MicroRNAs (miRNAs) exhibit many functions in biological activities. Recent studies have shown that miRNAs exist outside cells and are transferred between cells. Extracellular miRNAs are protected from ribonucleases found in body fluids through binding to specific proteins or by being encapsulated in lipid bilayer vesicles. Here, we review the mechanisms of the secretion and uptake as well as the functions of extracellular miRNAs, particularly those encapsulated in extracellular vesicles. Extracellular vesicles are related to cancer progression, and some miRNAs in extracellular vesicles are associated with cancer cells. We describe the transfer of cancer-related miRNAs between cancer cells and non-cancerous cells. Finally, we discuss the anticipated applications of miRNAs present in extracellular vesicles in diagnostics and therapeutics. The Author(s), 2015 Extracellular RNA nationallicence Extracellular vesicle (EV) nationallicence Exosome nationallicence MicroRNA (miRNA) nationallicence Cancer nationallicence Cancer therapy nationallicence Nishida-Aoki Nao Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan aut Ochiya Takahiro Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan aut Cellular and Molecular Life Sciences Springer Basel 72/10(2015-05-01), 1849-1861 1420-682X 72:10<1849 2015 72 18 https://doi.org/10.1007/s00018-014-1811-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1811-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nishida-Aoki Nao Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan aut NATIONALLICENCE 700 1- Ochiya Takahiro Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/10(2015-05-01), 1849-1861 1420-682X 72:10<1849 2015 72 18