caa a22 4500 60617608X CHVBK 20210128100746.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00018-015-1839-9 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1839-9 Cellular factors modulating the mechanism of tau protein aggregation [Elektronische Daten] [Sarah Fontaine, Jonathan Sabbagh, Jeremy Baker, Carlos Martinez-Licha, April Darling, Chad Dickey] Pathological accumulation of the microtubule-associated protein tau, in the form of neurofibrillary tangles, is a major hallmark of Alzheimer's disease, the most prevalent neurodegenerative condition worldwide. In addition to Alzheimer's disease, a number of neurodegenerative diseases, called tauopathies, are characterized by the accumulation of aggregated tau in a variety of brain regions. While tau normally plays an important role in stabilizing the microtubule network of the cytoskeleton, its dissociation from microtubules and eventual aggregation into pathological deposits is an area of intense focus for therapeutic development. Here we discuss the known cellular factors that affect tau aggregation, from post-translational modifications to molecular chaperones. Springer Basel, 2015 Tau nationallicence Alzheimer's disease nationallicence Tauopathy nationallicence Aggregation nationallicence Fontaine Sarah Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut Sabbagh Jonathan Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut Baker Jeremy Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut Martinez-Licha Carlos Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut Darling April Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut Dickey Chad Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut Cellular and Molecular Life Sciences Springer Basel 72/10(2015-05-01), 1863-1879 1420-682X 72:10<1863 2015 72 18 https://doi.org/10.1007/s00018-015-1839-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1839-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fontaine Sarah Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut NATIONALLICENCE 700 1- Sabbagh Jonathan Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut NATIONALLICENCE 700 1- Baker Jeremy Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut NATIONALLICENCE 700 1- Martinez-Licha Carlos Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut NATIONALLICENCE 700 1- Darling April Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut NATIONALLICENCE 700 1- Dickey Chad Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, 33613, Tampa, FL, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/10(2015-05-01), 1863-1879 1420-682X 72:10<1863 2015 72 18