caa a22 4500 606176098 CHVBK 20210128100746.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00018-015-1840-3 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1840-3 Dysregulated glycolysis as an oncogenic event [Elektronische Daten] [Takumi Mikawa, Matilde LLeonart, Akifumi Takaori-Kondo, Nobuya Inagaki, Masayuki Yokode, Hiroshi Kondoh] Enhanced glycolysis in cancer, called the Warburg effect, is a well-known feature of cancer metabolism. Recent advances revealed that the Warburg effect is coupled to many other cancer properties, including adaptation to hypoxia and low nutrients, immortalisation, resistance to oxidative stress and apoptotic stimuli, and elevated biomass synthesis. These linkages are mediated by various oncogenic molecules and signals, such as c-Myc, p53, and the insulin/Ras pathway. Furthermore, several regulators of glycolysis have been recently identified as oncogene candidates, including the hypoxia-inducible factor pathway, sirtuins, adenosine monophosphate-activated kinase, glycolytic pyruvate kinase M2, phosphoglycerate mutase, and oncometabolites. The interplay between glycolysis and oncogenic events will be the focus of this review. Springer Basel, 2015 Warburg effect nationallicence Cancer nationallicence HIF-1 nationallicence Sirtuin nationallicence Myc nationallicence PGAM nationallicence Mikawa Takumi Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, 606-8507, Kyoto, Japan aut LLeonart Matilde Department of Pathology, Hospital Vall de'Hebron, Paseo Vall d'Hebron 119-129, 08035, Barcelona, Spain aut Takaori-Kondo Akifumi Department of Hematology, Graduate School of Medicine, Kyoto University, 606-8507, Kyoto, Japan aut Inagaki Nobuya Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, 606-8507, Kyoto, Japan aut Yokode Masayuki Department of Clinical Innovative Medicine, Translational Research Center, Kyoto University Hospital, 606-8507, Kyoto, Japan aut Kondoh Hiroshi Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, 606-8507, Kyoto, Japan aut Cellular and Molecular Life Sciences Springer Basel 72/10(2015-05-01), 1881-1892 1420-682X 72:10<1881 2015 72 18 https://doi.org/10.1007/s00018-015-1840-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1840-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mikawa Takumi Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- LLeonart Matilde Department of Pathology, Hospital Vall de'Hebron, Paseo Vall d'Hebron 119-129, 08035, Barcelona, Spain aut NATIONALLICENCE 700 1- Takaori-Kondo Akifumi Department of Hematology, Graduate School of Medicine, Kyoto University, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Inagaki Nobuya Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Yokode Masayuki Department of Clinical Innovative Medicine, Translational Research Center, Kyoto University Hospital, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Kondoh Hiroshi Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, 606-8507, Kyoto, Japan aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/10(2015-05-01), 1881-1892 1420-682X 72:10<1881 2015 72 18