caa a22 4500 606176160 CHVBK 20210128100746.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00018-015-2029-5 doi (NATIONALLICENCE)springer-10.1007/s00018-015-2029-5 Neural map formation and sensory coding in the vomeronasal system [Elektronische Daten] [Alexandra Brignall, Jean-François Cloutier] Sensory systems enable us to encode a clear representation of our environment in the nervous system by spatially organizing sensory stimuli being received. The organization of neural circuitry to form a map of sensory activation is critical for the interpretation of these sensory stimuli. In rodents, social communication relies strongly on the detection of chemosignals by the vomeronasal system, which regulates a wide array of behaviours, including mate recognition, reproduction, and aggression. The binding of these chemosignals to receptors on vomeronasal sensory neurons leads to activation of second-order neurons within glomeruli of the accessory olfactory bulb. Here, vomeronasal receptor activation by a stimulus is organized into maps of glomerular activation that represent phenotypic qualities of the stimuli detected. Genetic, electrophysiological and imaging studies have shed light on the principles underlying cell connectivity and sensory map formation in the vomeronasal system, and have revealed important differences in sensory coding between the vomeronasal and main olfactory system. In this review, we summarize the key factors and mechanisms that dictate circuit formation and sensory coding logic in the vomeronasal system, emphasizing differences with the main olfactory system. Furthermore, we discuss how detection of chemosignals by the vomeronasal system regulates social behaviour in mice, specifically aggression. Springer Basel, 2015 Vomeronasal system nationallicence Axonal guidance nationallicence Sensory coding nationallicence Glomerular maps nationallicence Aggression nationallicence Brignall Alexandra Montreal Neurological Institute, Centre for Neuronal Survival, 3801 University, Room MP105, H3A 2B4, Montréal, QC, Canada aut Cloutier Jean-François Montreal Neurological Institute, Centre for Neuronal Survival, 3801 University, Room MP105, H3A 2B4, Montréal, QC, Canada aut Cellular and Molecular Life Sciences Springer International Publishing 72/24(2015-12-01), 4697-4709 1420-682X 72:24<4697 2015 72 18 https://doi.org/10.1007/s00018-015-2029-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2029-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brignall Alexandra Montreal Neurological Institute, Centre for Neuronal Survival, 3801 University, Room MP105, H3A 2B4, Montréal, QC, Canada aut NATIONALLICENCE 700 1- Cloutier Jean-François Montreal Neurological Institute, Centre for Neuronal Survival, 3801 University, Room MP105, H3A 2B4, Montréal, QC, Canada aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer International Publishing 72/24(2015-12-01), 4697-4709 1420-682X 72:24<4697 2015 72 18