caa a22 4500 606176225 CHVBK 20210128100746.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00018-015-2038-4 doi (NATIONALLICENCE)springer-10.1007/s00018-015-2038-4 Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases? [Elektronische Daten] [Natalia de Groot, Marc Burgas] Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. Specifically, we describe the processes that generate such imbalances at the molecular level, and try to understand how they affect protein folding and localization. Overall, current knowledge suggests that microglia pro-inflammatory mediators can generate membrane damage, which may have an impact in terms of triggering or accelerating disease manifestation. Springer Basel, 2015 Protein aggregation nationallicence Neurodegenerative disease nationallicence Neuroinflammation nationallicence Membrane nationallicence Microglia nationallicence de Groot Natalia Laboratory of Molecular Biology (Medical Research Council), Francis Crick Avenue, CB2 0QH, Cambridge, UK aut Burgas Marc Laboratory of Molecular Biology (Medical Research Council), Francis Crick Avenue, CB2 0QH, Cambridge, UK aut Cellular and Molecular Life Sciences Springer International Publishing 72/24(2015-12-01), 4795-4805 1420-682X 72:24<4795 2015 72 18 https://doi.org/10.1007/s00018-015-2038-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2038-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Groot Natalia Laboratory of Molecular Biology (Medical Research Council), Francis Crick Avenue, CB2 0QH, Cambridge, UK aut NATIONALLICENCE 700 1- Burgas Marc Laboratory of Molecular Biology (Medical Research Council), Francis Crick Avenue, CB2 0QH, Cambridge, UK aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer International Publishing 72/24(2015-12-01), 4795-4805 1420-682X 72:24<4795 2015 72 18