caa a22 4500 606176241 CHVBK 20210128100746.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00018-015-2030-z doi (NATIONALLICENCE)springer-10.1007/s00018-015-2030-z The role of deubiquitinating enzymes in spermatogenesis [Elektronische Daten] [Bharathi Suresh, Junwon Lee, Seok-Ho Hong, Kye-Seong Kim, Suresh Ramakrishna] Spermatogenesis is a complex process through which spermatogonial stem cells undergo mitosis, meiosis, and cell differentiation to generate mature spermatozoa. During this process, male germ cells experience several translational modifications. One of the major post-translational modifications in eukaryotes is the ubiquitination of proteins, which targets proteins for degradation; this enables control of the expression of enzymes and structural proteins during spermatogenesis. It has become apparent that ubiquitination plays a key role in regulating every stage of spermatogenesis starting from gonocytes to differentiated spermatids. It is understood that, where there is ubiquitination, deubiquitination by deubiquitinating enzymes (DUBs) also exists to counterbalance the ubiquitination process in a reversible manner. Normal spermatogenesis is dependent on the balanced actions of ubiquitination and deubiquitination. This review highlights the current knowledge of the role of DUBs and their essential regulatory contribution to spermatogenesis, especially during progression into meiotic phase, acrosome biogenesis, quality sperm production, and apoptosis of germ cells. Springer Basel, 2015 Acrosome nationallicence Gonocytes nationallicence Male infertility nationallicence Nucleosome nationallicence Proteasome nationallicence Protein degradation nationallicence Spermiogenesis nationallicence Ubiquitin nationallicence DUBs : Deubiquitinating enzymes nationallicence UPS : Ubiquitin proteasome system nationallicence UCH : Ubiquitin C-terminal hydrolases nationallicence USP : Ubiquitin-specific processing proteases nationallicence JAMM : Jab1/Pab1/MPN domain-containing metalloenzymes nationallicence OTU : Otu-domain ubiquitin aldehyde-binding proteins nationallicence MCPIPs : Monocyte chemotactic protein-induced proteases nationallicence MIT : Microtubule interacting and transport domain nationallicence AZF : Azoospermia factor nationallicence AR : Androgen receptor nationallicence ax : Ataxia nationallicence SNPs : Single nucleotide polymorphism nationallicence CYLD : Cylindromatosis nationallicence RIP1 : Receptor-interacting protein 1 nationallicence Suresh Bharathi Graduate School of Biomedical Science and Engineering, Hanyang University, Seongdong-gu, Seoul, South Korea aut Lee Junwon Department of Physiology and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea aut Hong Seok-Ho Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, South Korea aut Kim Kye-Seong Graduate School of Biomedical Science and Engineering, Hanyang University, Seongdong-gu, Seoul, South Korea aut Ramakrishna Suresh Graduate School of Biomedical Science and Engineering, Hanyang University, Seongdong-gu, Seoul, South Korea aut Cellular and Molecular Life Sciences Springer International Publishing 72/24(2015-12-01), 4711-4720 1420-682X 72:24<4711 2015 72 18 https://doi.org/10.1007/s00018-015-2030-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2030-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suresh Bharathi Graduate School of Biomedical Science and Engineering, Hanyang University, Seongdong-gu, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Junwon Department of Physiology and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Hong Seok-Ho Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, South Korea aut NATIONALLICENCE 700 1- Kim Kye-Seong Graduate School of Biomedical Science and Engineering, Hanyang University, Seongdong-gu, Seoul, South Korea aut NATIONALLICENCE 700 1- Ramakrishna Suresh Graduate School of Biomedical Science and Engineering, Hanyang University, Seongdong-gu, Seoul, South Korea aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer International Publishing 72/24(2015-12-01), 4711-4720 1420-682X 72:24<4711 2015 72 18