caa a22 4500 606176268 CHVBK 20210128100746.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00018-015-2034-8 doi (NATIONALLICENCE)springer-10.1007/s00018-015-2034-8 Autophagy signal transduction by ATG proteins: from hierarchies to networks [Elektronische Daten] [Sebastian Wesselborg, Björn Stork] Autophagy represents an intracellular degradation process which is involved in both cellular homeostasis and disease settings. In the last two decades, the molecular machinery governing this process has been characterized in detail. To date, several key factors regulating this intracellular degradation process have been identified. The so-called autophagy-related (ATG) genes and proteins are central to this process. However, several additional molecules contribute to the outcome of an autophagic response. Several review articles describing the molecular process of autophagy have been published in the recent past. In this review article we would like to add the most recent findings to this knowledge, and to give an overview of the network character of the autophagy signaling machinery. The Author(s), 2015 Autophagy nationallicence ATG nationallicence ULK nationallicence PtdIns3K nationallicence LC3 nationallicence Wesselborg Sebastian Institute of Molecular Medicine I, Heinrich-Heine-University, Universitätsstr. 1, Building 23.12, 40225, Düsseldorf, Germany aut Stork Björn Institute of Molecular Medicine I, Heinrich-Heine-University, Universitätsstr. 1, Building 23.12, 40225, Düsseldorf, Germany aut Cellular and Molecular Life Sciences Springer International Publishing 72/24(2015-12-01), 4721-4757 1420-682X 72:24<4721 2015 72 18 https://doi.org/10.1007/s00018-015-2034-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2034-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wesselborg Sebastian Institute of Molecular Medicine I, Heinrich-Heine-University, Universitätsstr. 1, Building 23.12, 40225, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Stork Björn Institute of Molecular Medicine I, Heinrich-Heine-University, Universitätsstr. 1, Building 23.12, 40225, Düsseldorf, Germany aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer International Publishing 72/24(2015-12-01), 4721-4757 1420-682X 72:24<4721 2015 72 18