caa a22 4500 606176284 CHVBK 20210128100746.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00018-015-2044-6 doi (NATIONALLICENCE)springer-10.1007/s00018-015-2044-6 Neuronal correlates of depression [Elektronische Daten] [Dipesh Chaudhury, He Liu, Ming-Hu Han] Major depressive disorder (MDD) is a common psychiatric disorder effecting approximately 121 million people worldwide and recent reports from the World Health Organization (WHO) suggest that it will be the leading contributor to the global burden of diseases. At present, the most commonly used treatment strategies are still based on the monoamine hypothesis that has been the predominant theory in the last 60years. Clinical observations show that only a subset of depressed patients exhibits full remission when treated with classical monoamine-based antidepressants together with the fact that patients exhibit multiple symptoms suggest that the pathophysiology leading to mood disorders may differ between patients. Accumulating evidence indicates that depression is a neural circuit disorder and that onset of depression may be located at different regions of the brain involving different transmitter systems and molecular mechanisms. This review synthesises findings from rodent studies from which emerges a role for different, yet interconnected, molecular systems and associated neural circuits to the aetiology of depression. Springer Basel, 2015 Depression nationallicence Molecular signalling nationallicence Epigenetics nationallicence Neurogenesis nationallicence Immune nationallicence Neural circuit nationallicence Homeostasis nationallicence Circadian rhythm nationallicence Sleep deprivation nationallicence 3V : Third ventricle nationallicence 4V : Fourth ventricle nationallicence 5-HT : Serotonin nationallicence AMPA : α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid nationallicence Arc : Activity-regulated cytoskeleton-associated protein gene nationallicence BDNF : Brain-derived neurotrophic factor nationallicence BLA : Basolateral amygdala nationallicence Ca2+ : Calcium nationallicence CaMKII : Calcium/calmodulin-dependent protein kinase II nationallicence CeM : Central amygdala nationallicence CPP : 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid nationallicence CRF : Corticortrophin-releasing factor nationallicence CSD : Chronic social defeat nationallicence CUS : Chronic unpredictable stress nationallicence D1 : Dopamine 1 receptor nationallicence D2 : Dopamine 2 receptor nationallicence D3V : Dorsal third ventricle nationallicence DBS : Deep brain stimulation nationallicence delta FosB : Delta FBJ murine osteosarcoma viral oncogene homolog B nationallicence DMH : Dorsomedial nucleus of the hypothalamus nationallicence DNMT : DNA methyltransferase nationallicence DRN : Dorsal raphe nucleus nationallicence eEF2 : Eukaryotic elongation factor nationallicence Egr1 : Early growth response protein 1 gene nationallicence ERK1/2 : Extracellular signal regulated kinase nationallicence FosB : FBJ murine osteosarcoma viral oncogene homolog B nationallicence G9a : Histone H3 lysine 9 methyltransferase nationallicence GABA : Gamma-aminobutyric acid nationallicence GLP : Histone H3 lysine 9 methyltransferase nationallicence GluR1 : Glutamate receptor subunit 1 nationallicence GluR2 : Glutamate receptor subunit 2 nationallicence GluR3 : Glutamate receptor subunit 3 nationallicence GPo : Globus pallidum nationallicence H3K9me2 : Histone H3 dimethyl Lys9 nationallicence HATS : Histone acetyltransferase nationallicence HCN : Hyperpolarisation-activated cyclic nucleotide-gated channel nationallicence HDAC : Histone deacetylase nationallicence HDM : Histone demethylase nationallicence HMT : Histone methyltransferase nationallicence I h : Hyperpolarisation-activated non-selective cation current nationallicence IKK : IKB kinase nationallicence IKKdn : IKK dominant negative nationallicence IVF : In vitro fertilisation nationallicence K+ : Potassium nationallicence LC : Locus coeruleus nationallicence LDTg : Laterodorsal tegmental nucleus nationallicence LH : Lateral hypothalamus nationallicence LHb : Lateral habenula nationallicence LTD : Laterodorsal tegmentum nationallicence MAPK : Mitogen-activated protein kinases nationallicence MDD : Major depressive disorder nationallicence mGluR2 : Metabotropic glutamate receptor 2 nationallicence MK-801 : 5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine nationallicence mper1/2 : Period gene 1 and 2 nationallicence mPFC : Medial prefrontal cortex nationallicence MSN : Medium spiny neurons nationallicence mTOR : Mammalian target of rapamycin nationallicence NAc : Nucleus accumbens nationallicence NFkB : Nuclear factor kB nationallicence NMDAR : N-methyl-d-aspartate receptor nationallicence NR2B : NMDAR 2B subunit nationallicence PPTg : Pedunculopontine tegmental nucleus nationallicence REM : Rapid eye movement nationallicence RMTg : Rostromedial tegmental nucleus nationallicence SC1 : Sparc-like 1 nationallicence SCN : Suprachiasmatic nucleus nationallicence SD : Sleep deprivation nationallicence SDT : Sleep deprivation therapy nationallicence SN : Substrantia nigra nationallicence SPZ : Subparaventricular zone nationallicence SSRI : Serotonin selective reuptake inhibitor nationallicence SUV39H1 : Histone-lysine N-methyltransferase nationallicence vHIP : Ventral hippocampus nationallicence VP : Ventral pallidum nationallicence VSCC : Voltage sensitive calcium channels nationallicence VTA : Ventral tegmental area nationallicence WKY : Wistar Kyoto nationallicence ZFP : Zing-finger protein nationallicence Chaudhury Dipesh Division of Science, Experimental Research Building, Office 106, New York University Abu Dhabi (NYUAD), Saadiyat Island Campus, P.O. Box 129188, Abu Dhabi, United Arab Emirates aut Liu He Division of Science, Experimental Research Building, Office 106, New York University Abu Dhabi (NYUAD), Saadiyat Island Campus, P.O. Box 129188, Abu Dhabi, United Arab Emirates aut Han Ming-Hu Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA aut Cellular and Molecular Life Sciences Springer International Publishing 72/24(2015-12-01), 4825-4848 1420-682X 72:24<4825 2015 72 18 https://doi.org/10.1007/s00018-015-2044-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2044-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chaudhury Dipesh Division of Science, Experimental Research Building, Office 106, New York University Abu Dhabi (NYUAD), Saadiyat Island Campus, P.O. Box 129188, Abu Dhabi, United Arab Emirates aut NATIONALLICENCE 700 1- Liu He Division of Science, Experimental Research Building, Office 106, New York University Abu Dhabi (NYUAD), Saadiyat Island Campus, P.O. Box 129188, Abu Dhabi, United Arab Emirates aut NATIONALLICENCE 700 1- Han Ming-Hu Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer International Publishing 72/24(2015-12-01), 4825-4848 1420-682X 72:24<4825 2015 72 18