caa a22 4500 606176349 CHVBK 20210128100747.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00018-015-1926-y doi (NATIONALLICENCE)springer-10.1007/s00018-015-1926-y Cytoplasmic dynein and early endosome transport [Elektronische Daten] [Xin Xiang, Rongde Qiu, Xuanli Yao, Herbert Arst Jr., Miguel Peñalva, Jun Zhang] Microtubule-based distribution of organelles/vesicles is crucial for the function of many types of eukaryotic cells and the molecular motor cytoplasmic dynein is required for transporting a variety of cellular cargos toward the microtubule minus ends. Early endosomes represent a major cargo of dynein in filamentous fungi, and dynein regulators such as LIS1 and the dynactin complex are both required for early endosome movement. In fungal hyphae, kinesin-3 and dynein drive bi-directional movements of early endosomes. Dynein accumulates at microtubule plus ends; this accumulation depends on kinesin-1 and dynactin, and it is important for early endosome movements towards the microtubule minus ends. The physical interaction between dynein and early endosome requires the dynactin complex, and in particular, its p25 component. The FTS-Hook-FHIP (FHF) complex links dynein-dynactin to early endosomes, and within the FHF complex, Hook interacts with dynein-dynactin, and Hook-early endosome interaction depends on FHIP and FTS. Springer Basel, 2015 Dynein nationallicence Kinesin nationallicence Dynactin nationallicence LIS1 nationallicence Endosome nationallicence Hook nationallicence Fungi nationallicence Aspergillus nationallicence Ustilago nationallicence Xiang Xin Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA aut Qiu Rongde Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA aut Yao Xuanli Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA aut Arst Jr. Herbert Microbiology Section, Department of Medicine, Imperial College London, SW7 2AZ, London, UK aut Peñalva Miguel Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas CSIC, Ramiro de Maeztu 9, 28040, Madrid, Spain aut Zhang Jun Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA aut Cellular and Molecular Life Sciences Springer Basel 72/17(2015-09-01), 3267-3280 1420-682X 72:17<3267 2015 72 18 https://doi.org/10.1007/s00018-015-1926-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1926-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xiang Xin Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Qiu Rongde Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Yao Xuanli Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Arst Jr Herbert Microbiology Section, Department of Medicine, Imperial College London, SW7 2AZ, London, UK aut NATIONALLICENCE 700 1- Peñalva Miguel Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas CSIC, Ramiro de Maeztu 9, 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Zhang Jun Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/17(2015-09-01), 3267-3280 1420-682X 72:17<3267 2015 72 18