caa a22 4500 606176365 CHVBK 20210128100747.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00018-015-1924-0 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1924-0 Downstream effects of endocannabinoid on blood cells: implications for health and disease [Elektronische Daten] [Valeria Gasperi, Daniela Evangelista, Isabella Savini, Domenico Del Principe, Luciana Avigliano, Mauro Maccarrone, Maria Catani] Endocannabinoids (eCBs), among which N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) are the most biologically active members, are polyunsaturated lipids able to bind cannabinoid, vanilloid and peroxisome proliferator-activated receptors. Depending on the target engaged, these bioactive mediators can regulate different signalling pathways, at both central and peripheral levels. The biological action of eCBs is tightly controlled by a plethora of metabolic enzymes which, together with the molecular targets of these substances, form the so-called "endocannabinoid system”. The ability of eCBs to control manifold peripheral functions has received a great deal of attention, especially in the light of their widespread distribution in the body. In particular, eCBs are important regulators in blood, where they modulate haematopoiesis, platelet aggregation and apoptosis, as well as chemokine release and migration of immunocompetent cells. Here, we shall review the current knowledge on the pathophysiological roles of eCBs in blood. We shall also discuss the involvement of eCBs in those disorders affecting the haematological system, including cancer and inflammation. Knowledge gained to date underlines a fundamental role of the eCB system in blood, thus suggesting that it may represent a therapeutic promise for a broad range of diseases involving impaired hematopoietic cell functions. Springer Basel, 2015 Bioactive lipids nationallicence Haematopoiesis nationallicence Leukocytes nationallicence Platelets nationallicence Cancer nationallicence Blood diseases nationallicence 2-AG : 2-Arachidonoylglycerol nationallicence Met-AEA : 2-methylarachidonyl-(2′-fluoroethyl)amide nationallicence ABHD : a/b-hydrolase nationallicence AML : Acute myeloid leukaemia nationallicence ApoE : Apolipoprotein E nationallicence CB : Cannabinoid nationallicence CM : Chronic migraine nationallicence eCB : Endocannabinoid nationallicence EMT : eCB membrane transporter nationallicence eNOS : Endothelial nitric oxide synthase nationallicence ERK : Extracellular signal-related kinase nationallicence FAAH : Fatty acid amide hydrolase nationallicence fMLP : Formyl-Met-Leu-Phe nationallicence G-CSF : Granulocyte-colony-stimulating factor nationallicence GM-CSF : Granulocyte-macrophage colony-stimulating factor nationallicence HETE-G : Hydroxyeicosatetraenoyl glycerylester nationallicence ( S )-HAEA : Hydroxyeicosatetraenoylethanolamide nationallicence IBD : Inflammatory bowel disease nationallicence IFNγ : Interferon γ nationallicence IL : Interleukin nationallicence LTB4 : Leukotriene B4 nationallicence LPS : Lipopolysaccharide nationallicence MCP-1 : Macrophage-chemotactic protein 1 nationallicence MMP-9 : Matrix metalloprotease-9 nationallicence MOH : Medication-overuse headache nationallicence MAGL : Monoacylglyceride lipase nationallicence MS : Multiple sclerosis nationallicence NAPE-PLD : N-acylphosphatydiletanolamine phospholipase D nationallicence anandamide, AEA : N-arachidonoylethanolamine nationallicence NK : Natural killer nationallicence NO : Nitric oxide nationallicence PEA : N-palmitoylethanolamine nationallicence OEA : N-oleoylethanolamine nationallicence PPARs : Peroxisome proliferator-activated receptors nationallicence PI3K : Phosphoinositide 3kinase nationallicence PGE2 : Prostaglandin E2 nationallicence Th : T helper nationallicence TRPV1 : Transient receptor potential vanilloid 1 nationallicence TNFα : Tumour necrosis factor α nationallicence CB1 : Type-1 cannabinoid receptor nationallicence CB2 : Type-2 cannabinoid receptor nationallicence Gasperi Valeria Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy aut Evangelista Daniela Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy aut Savini Isabella Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy aut Del Principe Domenico San Raffaele Institute Sulmona, L'Aquila, Italy aut Avigliano Luciana Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy aut Maccarrone Mauro Center of Integrated Research, Campus Bio-Medico University of Rome, Rome, Italy aut Catani Maria Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy aut Cellular and Molecular Life Sciences Springer Basel 72/17(2015-09-01), 3235-3252 1420-682X 72:17<3235 2015 72 18 https://doi.org/10.1007/s00018-015-1924-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1924-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gasperi Valeria Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Evangelista Daniela Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Savini Isabella Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Del Principe Domenico San Raffaele Institute Sulmona, L'Aquila, Italy aut NATIONALLICENCE 700 1- Avigliano Luciana Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Maccarrone Mauro Center of Integrated Research, Campus Bio-Medico University of Rome, Rome, Italy aut NATIONALLICENCE 700 1- Catani Maria Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/17(2015-09-01), 3235-3252 1420-682X 72:17<3235 2015 72 18