caa a22 4500 60617639X CHVBK 20210128100747.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00018-015-1923-1 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1923-1 The role of clock genes and circadian rhythm in the development of cardiovascular diseases [Elektronische Daten] [Norihiko Takeda, Koji Maemura] The time of onset of cardiovascular disorders such as myocardial infarctions or ventricular arrhythmias exhibits a circadian rhythm. Diurnal variations in autonomic nervous activity, plasma cortisol level or renin-angiotensin activity underlie the pathogenesis of cardiovascular diseases. Transcriptional-translational feedback loop of the clock genes constitute a molecular clock system. In addition to the central clock in the suprachiasmatic nucleus, clock genes are also expressed in a circadian fashion in each organ to make up the peripheral clock. The peripheral clock seems to be beneficial for anticipating external stimuli and thus contributes to the maintenance of organ homeostasis. Loss of synchronization between the central and peripheral clocks also augments disease progression. Moreover, accumulating evidence shows that clock genes affect inflammatory and intracellular metabolic signaling. Elucidating the roles of the molecular clock in cardiovascular pathology through the identification of clock controlled genes will help to establish a novel therapeutic approach for cardiovascular disorders. Springer Basel, 2015 Biological clock nationallicence Molecular clock nationallicence Myocardial infarction nationallicence Endothelial function nationallicence Heart nationallicence Vasculature nationallicence Arrhythmia nationallicence CCG : Clock-controlled gene nationallicence SCN : Suprachiasmatic nucleus nationallicence ANP : Atrial natriuretic peptide nationallicence PAR : Proline and acid-rich nationallicence LV : Left ventricle nationallicence MI : Myocardial infarction nationallicence L/D : Light/dark nationallicence TAC : Transverse aortic constriction nationallicence CCM : Cardiomyocyte-specific clock mutant nationallicence NO : Nitric oxide nationallicence eNOS : Endothelial NO synthase nationallicence PAI-1 : Plasminogen activator inhibitor-1 nationallicence VT/VF : Ventricular tachycardia/fibrillation nationallicence Takeda Norihiko Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Maemura Koji Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan aut Cellular and Molecular Life Sciences Springer Basel 72/17(2015-09-01), 3225-3234 1420-682X 72:17<3225 2015 72 18 https://doi.org/10.1007/s00018-015-1923-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1923-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takeda Norihiko Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Maemura Koji Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/17(2015-09-01), 3225-3234 1420-682X 72:17<3225 2015 72 18