caa a22 4500 606176403 CHVBK 20210128100747.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00018-015-1904-4 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1904-4 Molecular and cellular mechanisms that initiate pain and itch [Elektronische Daten] [Jialie Luo, Jing Feng, Shenbin Liu, Edgar Walters, Hongzhen Hu] Somatosensory neurons mediate our sense of touch. They are critically involved in transducing pain and itch sensations under physiological and pathological conditions, along with other skin-resident cells. Tissue damage and inflammation can produce a localized or systemic sensitization of our senses of pain and itch, which can facilitate our detection of threats in the environment. Although acute pain and itch protect us from further damage, persistent pain and itch are debilitating. Recent exciting discoveries have significantly advanced our knowledge of the roles of membrane-bound G protein-coupled receptors and ion channels in the encoding of information leading to pain and itch sensations. This review focuses on molecular and cellular events that are important in early stages of the biological processing that culminates in our senses of pain and itch. Springer Basel, 2015 Keratinocytes nationallicence Innate immune cells nationallicence Dorsal root ganglion nationallicence Mas-related G-protein-coupled receptors nationallicence Transient receptor potential channels nationallicence Neuropeptides nationallicence Luo Jialie Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, 660 S. Euclid Ave., 63110, St. Louis, MO, USA aut Feng Jing Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, 660 S. Euclid Ave., 63110, St. Louis, MO, USA aut Liu Shenbin Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, 660 S. Euclid Ave., 63110, St. Louis, MO, USA aut Walters Edgar Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin Street, 77030, Houston, TX, USA aut Hu Hongzhen Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, 660 S. Euclid Ave., 63110, St. Louis, MO, USA aut Cellular and Molecular Life Sciences Springer Basel 72/17(2015-09-01), 3201-3223 1420-682X 72:17<3201 2015 72 18 https://doi.org/10.1007/s00018-015-1904-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1904-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luo Jialie Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, 660 S. Euclid Ave., 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Feng Jing Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, 660 S. Euclid Ave., 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Liu Shenbin Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, 660 S. Euclid Ave., 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Walters Edgar Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin Street, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Hu Hongzhen Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, 660 S. Euclid Ave., 63110, St. Louis, MO, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/17(2015-09-01), 3201-3223 1420-682X 72:17<3201 2015 72 18