caa a22 4500 606176411 CHVBK 20210128100747.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00018-015-1930-2 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1930-2 An integrative view on sex differences in brain tumors [Elektronische Daten] [Tao Sun, Anya Plutynski, Stacey Ward, Joshua Rubin] Sex differences in human health and disease can range from undetectable to profound. Differences in brain tumor rates and outcome are evident in males and females throughout the world and regardless of age. These observations indicate that fundamental aspects of sex determination can impact the biology of brain tumors. It is likely that optimal personalized approaches to the treatment of male and female brain tumor patients will require recognizing and understanding the ways in which the biology of their tumors can differ. It is our view that sex-specific approaches to brain tumor screening and care will be enhanced by rigorously documenting differences in brain tumor rates and outcomes in males and females, and understanding the developmental and evolutionary origins of sex differences. Here we offer such an integrative perspective on brain tumors. It is our intent to encourage the consideration of sex differences in clinical and basic scientific investigations. The Author(s), 2015 Metabolism nationallicence Cancer nationallicence Immunity nationallicence Sex determination nationallicence Evolution nationallicence Sexual dimorphism nationallicence Sun Tao Department of Pediatrics, Washington University School of Medicine, St Louis, USA aut Plutynski Anya Department of Philosophy, Washington University in St Louis, St Louis, USA aut Ward Stacey Department of Pediatrics, Washington University School of Medicine, St Louis, USA aut Rubin Joshua Department of Pediatrics, Washington University School of Medicine, St Louis, USA aut Cellular and Molecular Life Sciences Springer Basel 72/17(2015-09-01), 3323-3342 1420-682X 72:17<3323 2015 72 18 https://doi.org/10.1007/s00018-015-1930-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1930-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sun Tao Department of Pediatrics, Washington University School of Medicine, St Louis, USA aut NATIONALLICENCE 700 1- Plutynski Anya Department of Philosophy, Washington University in St Louis, St Louis, USA aut NATIONALLICENCE 700 1- Ward Stacey Department of Pediatrics, Washington University School of Medicine, St Louis, USA aut NATIONALLICENCE 700 1- Rubin Joshua Department of Pediatrics, Washington University School of Medicine, St Louis, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/17(2015-09-01), 3323-3342 1420-682X 72:17<3323 2015 72 18