caa a22 4500 606176446 CHVBK 20210128100747.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00018-015-1900-8 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1900-8 Lemercier Claudie INSERM, UMR_S 1038, BGE (Large Scale Biology), 38054, Grenoble, France aut When our genome is targeted by pathogenic bacteria [Elektronische Daten] [Claudie Lemercier] Eukaryotic cells repair thousands of lesions arising in the genome at each cell cycle. The most hazardous damage is likely DNA double-strand breaks (DSB) that cleave the double helix backbone. DSBs occur naturally during T cell receptor and immunoglobulin gene recombination in lymphocytes. DSBs can also arise as a consequence of exogenous stresses (e.g., ionizing irradiation, chemotherapeutic drugs, viruses) or oxidative processes. An increasing number of studies have reported that infection with pathogenic bacteria also alters the host genome, producing DSB and other modifications on DNA. This review focuses on recent data on bacteria-induced DNA damage and the known strategies used by these pathogens to maintain a physiological niche in the host. Even after DNA repair in infected cells, "scars” often remain on chromosomes and might generate genomic instability at the next cell division. Chronic inflammation in tissue, combined with infection and DNA damage, can give rise to genomic instability and eventually cancer. A functional link between the DNA damage response and the innate immune response has been recently established. Pathogenic bacteria also highjack the host cell cycle, often acting on the stability of the master regulator p53, or dampen the DNA damage response to support bacterial replication in an appropriate reservoir. Except in a few cases, the molecular mechanisms responsible for DNA lesions are poorly understood, although ROS release during infection is a serious candidate for generating DNA breaks. Thus, chronic or repetitive infections with genotoxic bacteria represent a common source of DNA lesions that compromise host genome integrity. Springer Basel, 2015 Genotoxic bacteria nationallicence DNA damage nationallicence Double strand break nationallicence Genomic instability nationallicence Inflammation nationallicence Cancer nationallicence Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2665-2676 1420-682X 72:14<2665 2015 72 18 https://doi.org/10.1007/s00018-015-1900-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1900-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Lemercier Claudie INSERM, UMR_S 1038, BGE (Large Scale Biology), 38054, Grenoble, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2665-2676 1420-682X 72:14<2665 2015 72 18