caa a22 4500 606176470 CHVBK 20210128100747.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00018-015-1903-5 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1903-5 Wang Chao-Wen Institute of Plant and Microbial Biology, Academia Sinica, Nankang, 11529, Taipei, Taiwan aut Lipid droplet dynamics in budding yeast [Elektronische Daten] [Chao-Wen Wang] Eukaryotic cells store excess fatty acids as neutral lipids, predominantly triacylglycerols and sterol esters, in organelles termed lipid droplets (LDs) that bulge out from the endoplasmic reticulum. LDs are highly dynamic and contribute to diverse cellular functions. The catabolism of the storage lipids within LDs is channeled to multiple metabolic pathways, providing molecules for energy production, membrane building blocks, and lipid signaling. LDs have been implicated in a number of protein degradation and pathogen infection processes. LDs may be linked to prevalent human metabolic diseases and have marked potential for biofuel production. The knowledge accumulated on LDs in recent years provides a foundation for diverse, and even unexpected, future research. This review focuses on recent advances in LD research, emphasizing the diverse physiological roles of LDs in the model system of budding yeast. Springer Basel, 2015 Endoplasmic reticulum nationallicence Triacylglycerol nationallicence Sterol ester nationallicence Phospholipid nationallicence Membrane nationallicence Metabolism nationallicence ACAT : Acyl-CoA:cholesterol acyltransferase nationallicence ATGL : Adipose triacylglyceride lipase nationallicence CCT : CTP:phosphocholine cytidylyltransferase nationallicence CoA : Coenzyme A nationallicence CDP-DAG : Cytidine diphosphate-diacylglycerol nationallicence CTP : Cytidine triphosphate nationallicence DAG : Diacylglycerol nationallicence DGAT : Acyl-CoA:diacylglycerol acyltransferase nationallicence ER : Endoplasmic reticulum nationallicence ERAD : ER-associated protein degradation nationallicence FA : Fatty acid nationallicence FIT : Fat-inducing transcript nationallicence GPAT : Glycerol-3-phosphate acyltransferase nationallicence LD : Lipid droplet nationallicence lyso-PA : 1-acylglycerol-3-phosphate nationallicence MAG : Monoacylglycerol nationallicence PA : Phosphatidic acid nationallicence PAP : Phosphatidate phosphatase nationallicence PC : Phosphatidylcholine nationallicence PE : Phosphatidylethanolamine nationallicence PI : Phosphatidylinositol nationallicence PS : Phosphatidylserine nationallicence SE : Sterol ester nationallicence TAG : Triacylglycerol nationallicence Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2677-2695 1420-682X 72:14<2677 2015 72 18 https://doi.org/10.1007/s00018-015-1903-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1903-5 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Wang Chao-Wen Institute of Plant and Microbial Biology, Academia Sinica, Nankang, 11529, Taipei, Taiwan aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2677-2695 1420-682X 72:14<2677 2015 72 18