caa a22 4500 606176489 CHVBK 20210128100747.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00018-015-1907-1 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1907-1 Regulation of lung development and regeneration by the vascular system [Elektronische Daten] [Nicole Woik, Jens Kroll] Blood vessels have been described a long time ago as passive circuits providing sufficient blood supply to ensure proper distribution of oxygen and nutrition. Blood vessels are mainly formed during embryonic development and in the early postnatal period. In the adult, blood vessels are quiescent, but can be activated and subsequently induced under pathophysiological conditions, such as ischemia and tumor growth. Surprisingly, recent data have suggested an active function for blood vessels, named angiocrine signaling, releasing trophogens which regulate organ development and organ regeneration including in the pancreas, lung, tumor cells, liver and bone. Lung development is driven by hypoxia as well as an intense endothelial-epithelial interaction, and important mechanisms contributing to these processes have recently been identified. This review aims to summarize recent developments and concepts about embryonic pulmonary vascular development and lung regeneration. We discuss hypoxia-inducible factor HIF-2α and vascular endothelial growth factor VEGF as important mediators in lung development and focus on endothelial-epithelial interactions and angiocrine signaling mechanisms. Springer Basel, 2015 Angiogenesis nationallicence Lung development nationallicence Angiocrine signaling nationallicence Hypoxia-inducible factors nationallicence VEGF nationallicence Woik Nicole Department of Vascular Biology and Tumor Angiogenesis, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany aut Kroll Jens Department of Vascular Biology and Tumor Angiogenesis, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany aut Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2709-2718 1420-682X 72:14<2709 2015 72 18 https://doi.org/10.1007/s00018-015-1907-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1907-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Woik Nicole Department of Vascular Biology and Tumor Angiogenesis, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany aut NATIONALLICENCE 700 1- Kroll Jens Department of Vascular Biology and Tumor Angiogenesis, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2709-2718 1420-682X 72:14<2709 2015 72 18