caa a22 4500 606176500 CHVBK 20210128100748.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00018-015-1895-1 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1895-1 The development and function of thymic B cells [Elektronische Daten] [Jason Perera, Haochu Huang] Thymic B cells are a unique population of B lymphocytes that reside at the cortico-medullary junction of the thymus, an organ that is specialized for the development and selection of T cells. These B cells are distinct from peripheral B cells both in terms of their origin and phenotype. Multiple lines of evidence suggest that they develop within the thymus from B lineage-committed progenitors and are not recirculating peripheral B cells. Furthermore, thymic B cells have a highly activated phenotype. Because of their location in the thymic medulla, they have been thought to play a role in T cell negative selection. Thymic B cells are capable of inducing negative selection in a number of model antigen systems, including viral super antigen, peptides from immunoglobulin, and cognate self antigen presented by B cell receptor-mediated uptake. These findings establish thymic B cells as a novel and important population to study; however, much work remains to be done to understand how all of these unique aspects of thymic B cell biology inform their function. Springer Basel, 2015 B cell progenitors nationallicence Antigen presentation nationallicence Negative selection nationallicence Thymic development nationallicence Lineage commitment nationallicence T cell repertoire nationallicence Perera Jason Committee on Immunology, University of Chicago, Chicago, IL, USA aut Huang Haochu Committee on Immunology, University of Chicago, Chicago, IL, USA aut Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2657-2663 1420-682X 72:14<2657 2015 72 18 https://doi.org/10.1007/s00018-015-1895-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1895-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Perera Jason Committee on Immunology, University of Chicago, Chicago, IL, USA aut NATIONALLICENCE 700 1- Huang Haochu Committee on Immunology, University of Chicago, Chicago, IL, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2657-2663 1420-682X 72:14<2657 2015 72 18