caa a22 4500 606176519 CHVBK 20210128100748.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00018-015-1845-y doi (NATIONALLICENCE)springer-10.1007/s00018-015-1845-y Platelet-neutrophil interactions under thromboinflammatory conditions [Elektronische Daten] [Jing Li, Kyungho Kim, Andrew Barazia, Alan Tseng, Jaehyung Cho] Platelets primarily mediate hemostasis and thrombosis, whereas leukocytes are responsible for immune responses. Since platelets interact with leukocytes at the site of vascular injury, thrombosis and vascular inflammation are closely intertwined and occur consecutively. Recent studies using real-time imaging technology demonstrated that platelet-neutrophil interactions on the activated endothelium are an important determinant of microvascular occlusion during thromboinflammatory disease in which inflammation is coupled to thrombosis. Although the major receptors and counter receptors have been identified, it remains poorly understood how heterotypic platelet-neutrophil interactions are regulated under disease conditions. This review discusses our current understanding of the regulatory mechanisms of platelet-neutrophil interactions in thromboinflammatory disease. Springer Basel, 2015 Vascular disease nationallicence Cell-cell interactions nationallicence Regulatory mechanisms nationallicence Surface receptors nationallicence Intracellular signaling nationallicence Sickle cell disease nationallicence Ischemic stroke nationallicence Li Jing Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, 60612, Chicago, IL, USA aut Kim Kyungho Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, 60612, Chicago, IL, USA aut Barazia Andrew Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, 60612, Chicago, IL, USA aut Tseng Alan Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, 60612, Chicago, IL, USA aut Cho Jaehyung Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, 60612, Chicago, IL, USA aut Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2627-2643 1420-682X 72:14<2627 2015 72 18 https://doi.org/10.1007/s00018-015-1845-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1845-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Jing Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- Kim Kyungho Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- Barazia Andrew Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- Tseng Alan Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- Cho Jaehyung Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, 60612, Chicago, IL, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2627-2643 1420-682X 72:14<2627 2015 72 18