caa a22 4500 606176535 CHVBK 20210128100748.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00018-015-1892-4 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1892-4 Regulation of intestinal IgA responses [Elektronische Daten] [Na Xiong, Shaomin Hu] The intestine harbors enormous numbers of commensal bacteria and is under frequent attack from food-borne pathogens and toxins. A properly regulated immune response is critical for homeostatic maintenance of commensals and for protection against infection and toxins in the intestine. Immunoglobulin A (IgA) isotype antibodies function specifically in mucosal sites such as the intestines to help maintain intestinal health by binding to and regulating commensal microbiota, pathogens and toxins. IgA antibodies are produced by intestinal IgA antibody-secreting plasma cells generated in gut-associated lymphoid tissues from naïve B cells in response to stimulations of the intestinal bacteria and components. Research on generation, migration, and maintenance of IgA-secreting cells is important in our effort to understand the biology of IgA responses and to help better design vaccines against intestinal infections. Springer Basel, 2015 IgA antibody nationallicence IgA antibody-secreting plasma cells nationallicence Follicular T helper cells nationallicence Migration and localization nationallicence Chemokine receptor nationallicence IgA memory nationallicence AID : Activation-induced cytidine deaminase nationallicence APRIL : A proliferation-inducing ligand nationallicence BAFF : B cell activating factor nationallicence BCMA : B cell maturation antigen nationallicence BCR : B cell receptor nationallicence CP : Caecal patch nationallicence CSR : Class switch recombination nationallicence CT : Cholera toxin nationallicence DC : Dendritic cell nationallicence GALT : Gut-associated lymphoid tissue nationallicence GF : Germ-free nationallicence IgA : Immunoglobulin A nationallicence IgA-ASC : IgA antibody-secreting plasma cell nationallicence IgH : Immunoglobulin heavy chain nationallicence ILC : Innate lymphoid cell nationallicence ILF : Isolated lymphoid follicle nationallicence LP : Lamina propria nationallicence LTi : Lymphoid tissue inducer nationallicence MLN : Mesenteric lymph node nationallicence PD-1 : Programmed cell death-1 nationallicence pDC : Plasmacytoid dendritic cell nationallicence pIgR : Polymeric immunoglobulin receptor nationallicence PP : Peyer's patch nationallicence RA : Retinoic acid nationallicence RAG : Recombinase-activating gene nationallicence SFB : Segmented filamentous bacteria nationallicence SHM : Somatic hypermutation nationallicence SIgA : Secretory IgA nationallicence TCR : T cell receptor nationallicence Tfh : Follicular T help nationallicence Tfr : Follicular regulatory T nationallicence TGF-β1 : Transforming growth factor β1 nationallicence TH17 : T helper 17 nationallicence Treg : Regulatory T nationallicence Xiong Na Department of Veterinary and Biomedical Sciences, Centre for Molecular Immunology and Infectious Disease, The Pennsylvania State University, 115 Henning Building, 16802, University Park, PA, USA aut Hu Shaomin Department of Veterinary and Biomedical Sciences, Centre for Molecular Immunology and Infectious Disease, The Pennsylvania State University, 115 Henning Building, 16802, University Park, PA, USA aut Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2645-2655 1420-682X 72:14<2645 2015 72 18 https://doi.org/10.1007/s00018-015-1892-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1892-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xiong Na Department of Veterinary and Biomedical Sciences, Centre for Molecular Immunology and Infectious Disease, The Pennsylvania State University, 115 Henning Building, 16802, University Park, PA, USA aut NATIONALLICENCE 700 1- Hu Shaomin Department of Veterinary and Biomedical Sciences, Centre for Molecular Immunology and Infectious Disease, The Pennsylvania State University, 115 Henning Building, 16802, University Park, PA, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/14(2015-07-01), 2645-2655 1420-682X 72:14<2645 2015 72 18