caa a22 4500 606176586 CHVBK 20210128100748.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00018-014-1764-3 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1764-3 Formation and role of exosomes in cancer [Elektronische Daten] [Lindsey Brinton, Hillary Sloane, Mark Kester, Kimberly Kelly] Exosomes offer new insight into cancer biology with both diagnostic and therapeutic implications. Because of their cell-to-cell communication, exosomes influence tumor progression, metastasis, and therapeutic efficacy. They can be isolated from blood and other bodily fluids to reveal disease processes occurring within the body, including cancerous growth. In addition to being a reservoir of cancer biomarkers, they can be re-engineered to reinstate tumor immunity. Tumor exosomes interact with various cells of the microenvironment to confer tumor-advantageous changes that are responsible for stromal activation, induction of the angiogenic switch, increased vascular permeability, and immune escape. Exosomes also contribute to metastasis by aiding in the epithelial-to-mesenchymal transition and formation of the pre-metastatic niche. Furthermore, exosomes protect tumor cells from the cytotoxic effects of chemotherapy drugs and transfer chemoresistance properties to nearby cells. Thus, exosomes are essential to many lethal elements of cancer and it is important to understand their biogenesis and role in cancer. Springer Basel, 2014 Signaling nationallicence Immunosurveillance nationallicence Fibroblast nationallicence Targeted therapy nationallicence Multivesicular endosome nationallicence Vaccine nationallicence ESCRT nationallicence Biogenesis nationallicence MVE : Multivesicular endosome nationallicence ESCRT : Endosomal-sorting complexes required for transport nationallicence MDSC : Myeloid-derived suppressor cells nationallicence EMT : Epithelial-to-mesenchymal transition nationallicence HIF : Hypoxia-inducible factor nationallicence GM-CSF : Granulocyte-macrophage colony-stimulating factor nationallicence ASC : Adipose stem cell nationallicence Brinton Lindsey Department of Biomedical Engineering, University of Virginia, PO Box 800759 Health System, 22908, Charlottesville, VA, USA aut Sloane Hillary Department of Chemistry, University of Virginia, PO Box 400319, 22904, Charlottesville, VA, USA aut Kester Mark Department of Pharmacology, University of Virginia School of Medicine, PO Box 800735, 22908, Charlottesville, VA, USA aut Kelly Kimberly Department of Biomedical Engineering, University of Virginia, PO Box 800759 Health System, 22908, Charlottesville, VA, USA aut Cellular and Molecular Life Sciences Springer Basel 72/4(2015-02-01), 659-671 1420-682X 72:4<659 2015 72 18 https://doi.org/10.1007/s00018-014-1764-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1764-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brinton Lindsey Department of Biomedical Engineering, University of Virginia, PO Box 800759 Health System, 22908, Charlottesville, VA, USA aut NATIONALLICENCE 700 1- Sloane Hillary Department of Chemistry, University of Virginia, PO Box 400319, 22904, Charlottesville, VA, USA aut NATIONALLICENCE 700 1- Kester Mark Department of Pharmacology, University of Virginia School of Medicine, PO Box 800735, 22908, Charlottesville, VA, USA aut NATIONALLICENCE 700 1- Kelly Kimberly Department of Biomedical Engineering, University of Virginia, PO Box 800759 Health System, 22908, Charlottesville, VA, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/4(2015-02-01), 659-671 1420-682X 72:4<659 2015 72 18