caa a22 4500 606176675 CHVBK 20210128100748.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1776-z doi (NATIONALLICENCE)springer-10.1007/s00018-014-1776-z Engrailed homeoproteins in visual system development [Elektronische Daten] [Andrea Wizenmann, Olivier Stettler, Kenneth Moya] Engrailed is a homeoprotein transcription factor. This family of transcription factors is characterized by their DNA-binding homeodomain and some members, including Engrailed, can transfer between cells and regulate protein translation in addition to gene transcription. Engrailed is intimately involved in the development of the vertebrate visual system. Early expression of Engrailed in dorsal mesencephalon contributes to the development and organization of a visual structure, the optic tectum/superior colliculus. This structure is an important target for retinal ganglion cell axons that carry visual information from the retina. Engrailed regulates the expression of Ephrin axon guidance cues in the tectum/superior colliculus. More recently it has been reported that Engrailed itself acts as an axon guidance cue in synergy with the Ephrin system and is proposed to enhance retinal topographic precision. The Author(s), 2014 Visual system nationallicence Retina nationallicence Tectum nationallicence Sensory map nationallicence Homeoprotein nationallicence Engrailed nationallicence Wizenmann Andrea Department of Anatomy, Institute of Clinical Anatomy and Cell Analysis, University of Tübingen, Österbergstrasse 3, 72074, Tübingen, Germany aut Stettler Olivier Laboratoire CRRET EAC 7149, Université Paris-Est Créteil, 61, Av. du Général de Gaulle, 94010, Créteil Cedex, France aut Moya Kenneth Collège de France, Center for Interdisciplinary Research in Biology, UMR CNRS 7241/INSERM U1050, 11 place Marcelin Berthelot, 75005, Paris, France aut Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1433-1445 1420-682X 72:8<1433 2015 72 18 https://doi.org/10.1007/s00018-014-1776-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1776-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wizenmann Andrea Department of Anatomy, Institute of Clinical Anatomy and Cell Analysis, University of Tübingen, Österbergstrasse 3, 72074, Tübingen, Germany aut NATIONALLICENCE 700 1- Stettler Olivier Laboratoire CRRET EAC 7149, Université Paris-Est Créteil, 61, Av. du Général de Gaulle, 94010, Créteil Cedex, France aut NATIONALLICENCE 700 1- Moya Kenneth Collège de France, Center for Interdisciplinary Research in Biology, UMR CNRS 7241/INSERM U1050, 11 place Marcelin Berthelot, 75005, Paris, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1433-1445 1420-682X 72:8<1433 2015 72 18