caa a22 4500 606176691 CHVBK 20210128100748.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1803-0 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1803-0 Nucleoside diphosphate kinases (NDPKs) in animal development [Elektronische Daten] [Krisztina Takács-Vellai, Tibor Vellai, Zsolt Farkas, Anil Mehta] In textbooks of biochemistry, nucleoside diphosphate conversion to a triphosphate by nucleoside diphosphate ‘kinases' (NDPKs, also named NME or NM23 proteins) merits a few lines of text. Yet this essential metabolic function, mediated by a multimeric phosphotransferase protein, has effects that lie beyond a simple housekeeping role. NDPKs attracted more attention when NM23-H1 was identified as the first metastasis suppressor gene. In this review, we examine these NDPK enzymes from a developmental perspective because of the tractable phenotypes found in simple animal models that point to common themes. The data suggest that NDPK enzymes control the availability of surface receptors to regulate cell-sensing cues during cell migration. NDPKs regulate different forms of membrane enclosure that engulf dying cells during development. We suggest that NDPK enzymes have been essential for the regulated uptake of objects such as bacteria or micronutrients, and this evolutionarily conserved endocytic function contributes to their activity towards the regulation of metastasis. Springer Basel, 2014 Nucleoside diphosphate kinases nationallicence NME nationallicence Metastasis inhibitor nationallicence Endocytosis nationallicence Dynamin nationallicence Engulfment nationallicence Takács-Vellai Krisztina Department of Biological Anthropology, Eötvös Loránd University, Pázmány Péter stny. 1/C, 1117, Budapest, Hungary aut Vellai Tibor Department of Genetics, Eötvös Loránd University, Pázmány Péter stny. 1/C, 1117, Budapest, Hungary aut Farkas Zsolt Department of Genetics, Eötvös Loránd University, Pázmány Péter stny. 1/C, 1117, Budapest, Hungary aut Mehta Anil Division of Medical Sciences, Centre for CVS and Lung Biology, Ninewells Hospital Medical School, DD19SY, Dundee, UK aut Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1447-1462 1420-682X 72:8<1447 2015 72 18 https://doi.org/10.1007/s00018-014-1803-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1803-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takács-Vellai Krisztina Department of Biological Anthropology, Eötvös Loránd University, Pázmány Péter stny. 1/C, 1117, Budapest, Hungary aut NATIONALLICENCE 700 1- Vellai Tibor Department of Genetics, Eötvös Loránd University, Pázmány Péter stny. 1/C, 1117, Budapest, Hungary aut NATIONALLICENCE 700 1- Farkas Zsolt Department of Genetics, Eötvös Loránd University, Pázmány Péter stny. 1/C, 1117, Budapest, Hungary aut NATIONALLICENCE 700 1- Mehta Anil Division of Medical Sciences, Centre for CVS and Lung Biology, Ninewells Hospital Medical School, DD19SY, Dundee, UK aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1447-1462 1420-682X 72:8<1447 2015 72 18