caa a22 4500 606176705 CHVBK 20210128100748.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1812-z doi (NATIONALLICENCE)springer-10.1007/s00018-014-1812-z Interactions between host factors and the skin microbiome [Elektronische Daten] [Adam SanMiguel, Elizabeth Grice] The skin is colonized by an assemblage of microorganisms which, for the most part, peacefully coexist with their hosts. In some cases, these communities also provide vital functions to cutaneous health through the modulation of host factors. Recent studies have illuminated the role of anatomical skin site, gender, age, and the immune system in shaping the cutaneous ecosystem. Alterations to microbial communities have also been associated with, and likely contribute to, a number of cutaneous disorders. This review focuses on the host factors that shape and maintain skin microbial communities, and the reciprocal role of microbes in modulating skin immunity. A greater understanding of these interactions is critical to elucidating the forces that shape cutaneous populations and their contributions to skin homeostasis. This knowledge can also inform the tendency of perturbations to predispose and/or bring about certain skin disorders. Springer Basel, 2014 Microbiome nationallicence Cutaneous immunity nationallicence Dermatology nationallicence Skin nationallicence Microbiota nationallicence OTU : Operational taxonomic unit nationallicence PCR : Polymerase chain reaction nationallicence qPCR : Quantitative polymerase chain reaction nationallicence LC : Langerhans cells nationallicence CLA : Cutaneous leukocyte antigen nationallicence HPV : Human papillomavirus nationallicence PID : Primary immunodeficiency nationallicence GF : Germ free nationallicence SPF : Specific pathogen free nationallicence AD : Atopic dermatitis nationallicence SanMiguel Adam Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, 421 Curie Blvd, 1007 Biomedical Research Building II/III, 19104, Philadelphia, PA, USA aut Grice Elizabeth Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, 421 Curie Blvd, 1007 Biomedical Research Building II/III, 19104, Philadelphia, PA, USA aut Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1499-1515 1420-682X 72:8<1499 2015 72 18 https://doi.org/10.1007/s00018-014-1812-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1812-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- SanMiguel Adam Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, 421 Curie Blvd, 1007 Biomedical Research Building II/III, 19104, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Grice Elizabeth Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, 421 Curie Blvd, 1007 Biomedical Research Building II/III, 19104, Philadelphia, PA, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1499-1515 1420-682X 72:8<1499 2015 72 18