caa a22 4500 606176713 CHVBK 20210128100748.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1817-7 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1817-7 Mammary lineage tracing: the coming of age [Elektronische Daten] [Sanja Sale, Kresimir Pavelic] Identification and characterization of the normal epithelial lineages in the mammary gland is a fundamental step in understanding both development and cellular origin of cancer. In contrast to other tissues where lineage tracing has been widely accepted as a method of choice for dissecting the stem cell hierarchy, mammary gland has long remained a challenge due to its unique developmental and topological features. Recent advances in high-resolution single-cell imaging, combined with the use of inducible Cre-recombinase and in situ cell ablation, have provided unprecedented insight into mammary epithelial cell composition and function. Here, we briefly summarize and compare different mammary gland lineage tracing strategies, examine associated caveats and discuss future challenges and opportunities. Springer Basel, 2015 Breast nationallicence Lineages nationallicence Fate mapping nationallicence In situ cell ablation nationallicence Cell-of-origin nationallicence Genetically engineered mouse models nationallicence Topological context nationallicence Sale Sanja Department of Biotechnology, University of Rijeka, Radmile Matejcic 2, 51000, Rijeka, Croatia aut Pavelic Kresimir Department of Biotechnology, University of Rijeka, Radmile Matejcic 2, 51000, Rijeka, Croatia aut Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1577-1583 1420-682X 72:8<1577 2015 72 18 https://doi.org/10.1007/s00018-014-1817-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1817-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sale Sanja Department of Biotechnology, University of Rijeka, Radmile Matejcic 2, 51000, Rijeka, Croatia aut NATIONALLICENCE 700 1- Pavelic Kresimir Department of Biotechnology, University of Rijeka, Radmile Matejcic 2, 51000, Rijeka, Croatia aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1577-1583 1420-682X 72:8<1577 2015 72 18