caa a22 4500 60617673X CHVBK 20210128100749.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1810-1 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1810-1 Molecular mechanism of mitochondrial calcium uptake [Elektronische Daten] [Lele Wang, Xue Yang, Yuequan Shen] Mitochondrial calcium uptake plays a critical role in various cellular functions. After half a century of extensive studies, the molecular components and important regulators of the mitochondrial calcium uptake complex have been identified. However, the mechanism by which these protein molecules interact with one another and coordinate to regulate calcium passage through mitochondrial membranes remains elusive. Here, we summarize recent progress in the structural and functional characterization of these important protein molecules, which are involved in mitochondrial calcium uptake. In particular, we focus on the current understanding of the molecular mechanism underlying calcium through two mitochondrial membranes. Additionally, we provide a new perspective for future directions in investigation and molecular intervention. Springer Basel, 2014 Calcium signaling nationallicence Calcium channel nationallicence VDAC nationallicence MCU nationallicence MICU nationallicence EMRE nationallicence MCUR1 nationallicence Wang Lele State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, 300071, Tianjin, China aut Yang Xue State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, 300071, Tianjin, China aut Shen Yuequan State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, 300071, Tianjin, China aut Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1489-1498 1420-682X 72:8<1489 2015 72 18 https://doi.org/10.1007/s00018-014-1810-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1810-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Lele State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, 300071, Tianjin, China aut NATIONALLICENCE 700 1- Yang Xue State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, 300071, Tianjin, China aut NATIONALLICENCE 700 1- Shen Yuequan State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, 300071, Tianjin, China aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1489-1498 1420-682X 72:8<1489 2015 72 18