caa a22 4500 606176764 CHVBK 20210128100749.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1808-8 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1808-8 Metabolic effects of resveratrol: addressing the controversies [Elektronische Daten] [Jacob Bitterman, Jay Chung] Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has received a great deal of attention for its diverse array of healthful effects. Beneficial effects of resveratrol are diverse; they include improvement of mitochondrial function, protection against obesity and obesity-related diseases such as type-2 diabetes, suppression of inflammation and cancer cell growth and protection against cardiovascular dysfunction, just to name a few. Investigations into the metabolic effects of resveratrol are furthest along and now include a number of clinical trials, which have yielded mixed results. There are a number of controversies surrounding resveratrol that have not been resolved. Here, we will review these controversies with particular emphasis on its mechanism of metabolic action and how lessons from resveratrol may help develop therapies that harness the effects of resveratrol but without the undesirable properties of resveratrol. Springer Basel (outside the USA), 2014 Resveratrol nationallicence Sirt1 nationallicence PDE4 nationallicence AMPK nationallicence AMPK : Adenosine monophosphate activated kinase nationallicence Sirt1 : Sirtuin 1 nationallicence SIR2 : Silent information regulator 2 nationallicence cAMP : Cyclic adenosine monophosphate nationallicence CAMKKβ : Calcium/calmodulin-dependent kinase kinase β nationallicence PDE : Phosphodiesterases nationallicence PKA : Protein kinase A nationallicence EPAC : Exchange protein activated by cAMP nationallicence COX : Cyclooxygenase nationallicence HOMA-IR : Homeostatic model assessment-insulin resistance nationallicence eNOS : Endothelial nitric oxide synthase nationallicence Nrf2 : Nuclear factor erythroid 2- related factor 2 nationallicence Bitterman Jacob Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive Building 10 Room 7D14, 20892, Bethesda, MD, USA aut Chung Jay Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive Building 10 Room 7D14, 20892, Bethesda, MD, USA aut Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1473-1488 1420-682X 72:8<1473 2015 72 18 https://doi.org/10.1007/s00018-014-1808-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1808-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bitterman Jacob Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive Building 10 Room 7D14, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Chung Jay Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive Building 10 Room 7D14, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1473-1488 1420-682X 72:8<1473 2015 72 18