caa a22 4500 606176772 CHVBK 20210128100749.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1813-y doi (NATIONALLICENCE)springer-10.1007/s00018-014-1813-y The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control [Elektronische Daten] [Alessandro Malara, Vittorio Abbonante, Christian Di Buduo, Lorenzo Tozzi, Manuela Currao, Alessandra Balduini] Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday production and release of millions of platelets into the bloodstream. Since the discovery and cloning, in 1994, of their principal humoral factor, thrombopoietin, and its receptor c-Mpl, many efforts have been directed to define the mechanisms underlying an efficient platelet production. However, more recently different studies have pointed out new roles for megakaryocytes as regulators of bone marrow homeostasis and physiology. In this review we discuss the interaction and the reciprocal regulation of megakaryocytes with the different cellular and extracellular components of the bone marrow environment. Finally, we provide evidence that these processes may concur to the reconstitution of the bone marrow environment after injury and their deregulation may lead to the development of a series of inherited or acquired pathologies. Springer Basel, 2015 Megakaryocytes (Mk) nationallicence Bone marrow (BM) nationallicence Vascular niche nationallicence Endothelial cells nationallicence Osteoblasts nationallicence Fibrosis nationallicence Myeloproliferative diseases nationallicence Thrombopoietin (Thpo) nationallicence Extracellular matrices (ECMs) nationallicence Malara Alessandro Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut Abbonante Vittorio Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut Di Buduo Christian Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut Tozzi Lorenzo Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut Currao Manuela Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut Balduini Alessandra Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1517-1536 1420-682X 72:8<1517 2015 72 18 https://doi.org/10.1007/s00018-014-1813-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1813-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Malara Alessandro Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Abbonante Vittorio Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Di Buduo Christian Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Tozzi Lorenzo Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Currao Manuela Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Balduini Alessandra Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/8(2015-04-01), 1517-1536 1420-682X 72:8<1517 2015 72 18