caa a22 4500 606176934 CHVBK 20210128100749.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00018-014-1778-x doi (NATIONALLICENCE)springer-10.1007/s00018-014-1778-x Sphingolipid metabolism and its role in the skeletal tissues [Elektronische Daten] [Zohreh Khavandgar, Monzur Murshed] The regulators affecting skeletal tissue formation and its maintenance include a wide array of molecules with very diverse functions. More recently, sphingolipids have been added to this growing list of regulatory molecules in the skeletal tissues. Sphingolipids are integral parts of various lipid membranes present in the cells and organelles. For a long time, these macromolecules were considered as inert structural elements. This view, however, has radically changed in recent years as sphingolipids are now recognized as important second messengers for signal-transduction pathways that affect cell growth, differentiation, stress responses and programmed death. In the current review, we discuss the available data showing the roles of various sphingolipids in three different skeletal cell types—chondrocytes in cartilage andosteoblasts and osteoclasts in bone. We provide an overview of the biology of sphingomyelin phosphodiesterase 3 (SMPD3), an important regulator of sphingolipid metabolism in the skeleton. SMPD3 is localized in the plasma membrane and has been shown to cleave sphingomyelin to generate ceramide, a bioactive lipid second messenger, and phosphocholine, an essential nutrient. SMPD3 deficiency in mice impairs the mineralization in both cartilage and bone extracellular matrices leading to severe skeletal deformities. A detailed understanding of SMPD3 function may provide a novel insight on the role of sphingolipids in the skeletal tissues. Springer Basel, 2014 Sphingolipids nationallicence SMPD3 nationallicence Neutral sphingomyelinase nationallicence Ceramide nationallicence Phosphocholine nationallicence Sphingosine 1 phosphate nationallicence Matrix vesicles nationallicence Skeletal development nationallicence Bone mineralization nationallicence fro/fro nationallicence Khavandgar Zohreh Faculty of Dentistry, McGill University, Montreal, Quebec, Canada aut Murshed Monzur Faculty of Dentistry, McGill University, Montreal, Quebec, Canada aut Cellular and Molecular Life Sciences Springer Basel 72/5(2015-03-01), 959-969 1420-682X 72:5<959 2015 72 18 https://doi.org/10.1007/s00018-014-1778-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1778-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khavandgar Zohreh Faculty of Dentistry, McGill University, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Murshed Monzur Faculty of Dentistry, McGill University, Montreal, Quebec, Canada aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/5(2015-03-01), 959-969 1420-682X 72:5<959 2015 72 18