caa a22 4500 606176969 CHVBK 20210128100750.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00018-015-2023-y doi (NATIONALLICENCE)springer-10.1007/s00018-015-2023-y Histone methylation modifiers in cellular signaling pathways [Elektronische Daten] [Hunain Alam, Bingnan Gu, Min Lee] Histone methyltransferases and demethylases epigenetically regulate gene expression by modifying histone methylation status in numerous cellular processes, including cell differentiation and proliferation. These modifiers also control methylation levels of various non-histone proteins, such as effector proteins that play critical roles in cellular signaling networks. Dysregulated histone methylation modifiers alter expression of oncogenes and tumor suppressor genes and change methylation states of effector proteins, frequently resulting in aberrant cellular signaling cascades and cellular transformation. In this review, we summarize the role of histone methylation modifiers in regulating the following signaling pathways: NF-κB, RAS/RAF/MEK/MAPK, PI3K/Akt, Wnt/β-catenin, p53, and ERα. Springer Basel, 2015 Histone methylation nationallicence Histone methyltransferase nationallicence Histone demethylase nationallicence Oncogenic signaling nationallicence Tumor suppressor pathway nationallicence Alam Hunain Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA aut Gu Bingnan Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA aut Lee Min Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA aut Cellular and Molecular Life Sciences Springer International Publishing 72/23(2015-12-01), 4577-4592 1420-682X 72:23<4577 2015 72 18 https://doi.org/10.1007/s00018-015-2023-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2023-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alam Hunain Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Gu Bingnan Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Lee Min Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer International Publishing 72/23(2015-12-01), 4577-4592 1420-682X 72:23<4577 2015 72 18