caa a22 4500 606176977 CHVBK 20210128100750.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00018-015-2031-y doi (NATIONALLICENCE)springer-10.1007/s00018-015-2031-y Role of the nucleus in apoptosis: signaling and execution [Elektronische Daten] [Evgeniia Prokhorova, Alexey Zamaraev, Gelina Kopeina, Boris Zhivotovsky, Inna Lavrik] Since their establishment in the early 1970s, the nuclear changes upon apoptosis induction, such as the condensation of chromatin, disassembly of nuclear scaffold proteins and degradation of DNA, were, and still are, considered as the essential steps and hallmarks of apoptosis. These are the characteristics of the execution phase of apoptotic cell death. In addition, accumulating data clearly show that some nuclear events can lead to the induction of apoptosis. In particular, if DNA lesions resulting from deregulation during the cell cycle or DNA damage induced by chemotherapeutic drugs or viral infection cannot be efficiently eliminated, apoptotic mechanisms, which enable cellular transformation to be avoided, are activated in the nucleus. The functional heterogeneity of the nuclear organization allows the tight regulation of these signaling events that involve the movement of various nuclear proteins to other intracellular compartments (and vice versa) to initiate and govern apoptosis. Here, we discuss how these events are coordinated to execute apoptotic cell death. Springer Basel, 2015 Caspases nationallicence Endonucleases nationallicence Ribosomal stress nationallicence PML nuclear bodies nationallicence p53 nationallicence p63 nationallicence p73 nationallicence Prokhorova Evgeniia Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut Zamaraev Alexey Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut Kopeina Gelina Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut Zhivotovsky Boris Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut Lavrik Inna Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut Cellular and Molecular Life Sciences Springer International Publishing 72/23(2015-12-01), 4593-4612 1420-682X 72:23<4593 2015 72 18 https://doi.org/10.1007/s00018-015-2031-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2031-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Prokhorova Evgeniia Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut NATIONALLICENCE 700 1- Zamaraev Alexey Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut NATIONALLICENCE 700 1- Kopeina Gelina Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut NATIONALLICENCE 700 1- Zhivotovsky Boris Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut NATIONALLICENCE 700 1- Lavrik Inna Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer International Publishing 72/23(2015-12-01), 4593-4612 1420-682X 72:23<4593 2015 72 18