caa a22 4500 606176985 CHVBK 20210128100750.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00018-015-2021-0 doi (NATIONALLICENCE)springer-10.1007/s00018-015-2021-0 Endothelial nitric oxide synthase in the microcirculation [Elektronische Daten] [Xiaohong Shu, T. Keller IV, Daniela Begandt, Joshua Butcher, Lauren Biwer, Alexander Keller, Linda Columbus, Brant Isakson] Endothelial nitric oxide synthase (eNOS, NOS3) is responsible for producing nitric oxide (NO)—a key molecule that can directly (or indirectly) act as a vasodilator and anti-inflammatory mediator. In this review, we examine the structural effects of regulation of the eNOS enzyme, including post-translational modifications and subcellular localization. After production, NO diffuses to surrounding cells with a variety of effects. We focus on the physiological role of NO and NO-derived molecules, including microvascular effects on vessel tone and immune response. Regulation of eNOS and NO action is complicated; we address endogenous and exogenous mechanisms of NO regulation with a discussion of pharmacological agents used in clinical and laboratory settings and a proposed role for eNOS in circulating red blood cells. Springer Basel, 2015 Endothelial nitric oxide synthase nationallicence Nitric oxide nationallicence Endothelium nationallicence Microcirculation nationallicence Shu Xiaohong College of Pharmacy, Dalian Medical University, 116044, Dalian, China aut Keller IV T. Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut Begandt Daniela Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut Butcher Joshua Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut Biwer Lauren Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut Keller Alexander Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut Columbus Linda Department of Chemistry, University of Virginia, Charlottesville, USA aut Isakson Brant Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut Cellular and Molecular Life Sciences Springer International Publishing 72/23(2015-12-01), 4561-4575 1420-682X 72:23<4561 2015 72 18 https://doi.org/10.1007/s00018-015-2021-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2021-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shu Xiaohong College of Pharmacy, Dalian Medical University, 116044, Dalian, China aut NATIONALLICENCE 700 1- Keller IV T. Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut NATIONALLICENCE 700 1- Begandt Daniela Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut NATIONALLICENCE 700 1- Butcher Joshua Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut NATIONALLICENCE 700 1- Biwer Lauren Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut NATIONALLICENCE 700 1- Keller Alexander Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut NATIONALLICENCE 700 1- Columbus Linda Department of Chemistry, University of Virginia, Charlottesville, USA aut NATIONALLICENCE 700 1- Isakson Brant Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, 22908, Charlottesville, VA, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer International Publishing 72/23(2015-12-01), 4561-4575 1420-682X 72:23<4561 2015 72 18