caa a22 4500 606177019 CHVBK 20210128100750.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00018-015-2014-z doi (NATIONALLICENCE)springer-10.1007/s00018-015-2014-z MUC1 (CD227): a multi-tasked molecule [Elektronische Daten] [Vasso Apostolopoulos, Lily Stojanovska, Sharron Gargosky] Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule. Springer Basel, 2015 MUC1 nationallicence CD227 nationallicence PEM nationallicence EMA nationallicence MUC1 isoforms nationallicence MUC1 expression nationallicence MUC1 structure nationallicence MUC1 and disease nationallicence MUC1 and pathogens nationallicence MUC1 and cancer nationallicence AGR2 : Anterior gradient 2 nationallicence ALK : Anaplastic lymphoma kinase nationallicence C. jejeni : Campylobacter jejeni nationallicence CA : Cancer antigen nationallicence CASA : Cancer-associated serum antigen nationallicence CD : Cluster of differentiation nationallicence CEA : Carcinoembryonic antigen nationallicence CTL : Cytotoxic T lymphocyte nationallicence DC : Dendritic cell nationallicence EGFR : Epidermal growth factor receptor nationallicence FGF : Fibroblast growth factor nationallicence GalNac : N-acetyl galactosamine nationallicence GlcNAc : N-acetyl glucosamine nationallicence H. pylori : Helicobacter pylori nationallicence HLA : Human leukocyte antigen nationallicence HMFG : Human milk fat globule nationallicence Hsp : Heat shock protein nationallicence IBD : Inflammatory bowel disease nationallicence ICAM-1 : Intercellular adhesion molecule 1 nationallicence IFN : Interferon nationallicence IL : Interleukin nationallicence Mab : Monoclonal antibody nationallicence MAG : Myelin-associated glycoprotein nationallicence MALT : Mucosa-associated lymphoid tissue nationallicence MAV-1 : Murine adenovirus type 1 nationallicence MCA : Mucin-like carcinoma-associated antigen nationallicence MDSC : Myeloid-derived suppressor cell nationallicence MGL : Macrophage galactose lectin nationallicence MHC : Major histocompatibility complex nationallicence MSA : Mammary serum antigen nationallicence MUC1 : Human mucin 1 nationallicence Muc1 : Other species mucin 1 nationallicence NK : Natural killer nationallicence NMR : Nuclear magnetic resonance nationallicence OSA : Ovarian serum antigen nationallicence P. aeruginosa : Pseudomonas aeruginosa nationallicence RSV : Respiratory syncytial virus nationallicence SEA : Sea urchin sperm protein-enterokinase-agrin nationallicence siRNA : Small interfering RNA nationallicence TF or T : Thomsen-Friedenreich nationallicence TGF : Transforming growth factor nationallicence Th : T helper nationallicence TLR : Toll-like receptor nationallicence TNF : Tumor necrosis factor nationallicence Tn : Monosaccharide of TF nationallicence STn : Sialylated Tn nationallicence VEGF : Vascular endothelial growth factor nationallicence VNTR : Variable number of tandem repeats nationallicence Apostolopoulos Vasso Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia aut Stojanovska Lily Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia aut Gargosky Sharron Prima BioMed Ltd, Sydney, NSW, Australia aut Cellular and Molecular Life Sciences Springer International Publishing 72/23(2015-12-01), 4475-4500 1420-682X 72:23<4475 2015 72 18 https://doi.org/10.1007/s00018-015-2014-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2014-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Apostolopoulos Vasso Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Stojanovska Lily Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Gargosky Sharron Prima BioMed Ltd, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer International Publishing 72/23(2015-12-01), 4475-4500 1420-682X 72:23<4475 2015 72 18