caa a22 4500 606177094 CHVBK 20210128100750.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1743-8 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1743-8 Of von Willebrand factor and platelets [Elektronische Daten] [Marijke Bryckaert, Jean-Philippe Rosa, Cécile Denis, Peter Lenting] Hemostasis and pathological thrombus formation are dynamic processes that require multiple adhesive receptor-ligand interactions, with blood platelets at the heart of such events. Many studies have contributed to shed light on the importance of von Willebrand factor (VWF) interaction with its platelet receptors, glycoprotein (GP) Ib-IX-V and αIIbβ3 integrin, in promoting primary platelet adhesion and aggregation following vessel injury. This review will recapitulate our current knowledge on the subject from the rheological aspect to the spatio-temporal development of thrombus formation. We will also discuss the signaling events generated by VWF/GPIb-IX-V interaction, leading to platelet activation. Additionally, we will review the growing body of evidence gathered from the recent development of pathological mouse models suggesting that VWF binding to GPIb-IX-V is a promising target in arterial and venous pathological thrombosis. Finally, the pathological aspects of VWF and its impact on platelets will be addressed. The Author(s), 2014 Platelets nationallicence von Willebrand factor nationallicence Glycoprotein Ib-IX-V nationallicence Hemostasis nationallicence Thrombosis nationallicence Bryckaert Marijke INSERM U770, Hôpital Bicêtre, 80 rue du Général Leclerc, 94276, Le Kremlin Bicêtre Cedex, France aut Rosa Jean-Philippe INSERM U770, Hôpital Bicêtre, 80 rue du Général Leclerc, 94276, Le Kremlin Bicêtre Cedex, France aut Denis Cécile INSERM U770, Hôpital Bicêtre, 80 rue du Général Leclerc, 94276, Le Kremlin Bicêtre Cedex, France aut Lenting Peter INSERM U770, Hôpital Bicêtre, 80 rue du Général Leclerc, 94276, Le Kremlin Bicêtre Cedex, France aut Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 307-326 1420-682X 72:2<307 2015 72 18 https://doi.org/10.1007/s00018-014-1743-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1743-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bryckaert Marijke INSERM U770, Hôpital Bicêtre, 80 rue du Général Leclerc, 94276, Le Kremlin Bicêtre Cedex, France aut NATIONALLICENCE 700 1- Rosa Jean-Philippe INSERM U770, Hôpital Bicêtre, 80 rue du Général Leclerc, 94276, Le Kremlin Bicêtre Cedex, France aut NATIONALLICENCE 700 1- Denis Cécile INSERM U770, Hôpital Bicêtre, 80 rue du Général Leclerc, 94276, Le Kremlin Bicêtre Cedex, France aut NATIONALLICENCE 700 1- Lenting Peter INSERM U770, Hôpital Bicêtre, 80 rue du Général Leclerc, 94276, Le Kremlin Bicêtre Cedex, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 307-326 1420-682X 72:2<307 2015 72 18