caa a22 4500 606177116 CHVBK 20210128100750.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1748-3 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1748-3 Histone chaperone CAF-1: essential roles in multi-cellular organism development [Elektronische Daten] [Zhongsheng Yu, Jiyong Liu, Wu-Min Deng, Renjie Jiao] More and more studies have shown chromatin remodelers and histone modifiers play essential roles in regulating developmental patterns by organizing specific chromosomal architecture to establish programmed transcriptional profiles, with implications that histone chaperones execute a coordinating role in these processes. Chromatin assembly factor-1 (CAF-1), an evolutionarily conserved three-subunit protein complex, was identified as a histone chaperone coupled with DNA replication and repair in cultured mammalian cells and yeasts. Interestingly, recent findings indicate CAF-1 may have important regulatory roles during development by interacting with specific transcription factors and epigenetic regulators. In this review, we focus on the essential roles of CAF-1 in regulating heterochromatin organization, asymmetric cell division, and specific signal transduction through epigenetic modulations of the chromatin. In the end, we aim at providing a current image of facets of CAF-1 as a histone chaperone to orchestrate cell proliferation and differentiation during multi-cellular organism development. Springer Basel, 2014 Heterochromatin nationallicence Signal transduction nationallicence Cell proliferation nationallicence Cell differentiation nationallicence Epigenetic regulation nationallicence Genome stability nationallicence Yu Zhongsheng State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Datun Road 15, 100101, Beijing, China aut Liu Jiyong State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Datun Road 15, 100101, Beijing, China aut Deng Wu-Min Department of Biological Science, Florida State University, 32304-4295, Tallahassee, FL, USA aut Jiao Renjie State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Datun Road 15, 100101, Beijing, China aut Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 327-337 1420-682X 72:2<327 2015 72 18 https://doi.org/10.1007/s00018-014-1748-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1748-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yu Zhongsheng State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Datun Road 15, 100101, Beijing, China aut NATIONALLICENCE 700 1- Liu Jiyong State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Datun Road 15, 100101, Beijing, China aut NATIONALLICENCE 700 1- Deng Wu-Min Department of Biological Science, Florida State University, 32304-4295, Tallahassee, FL, USA aut NATIONALLICENCE 700 1- Jiao Renjie State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Datun Road 15, 100101, Beijing, China aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 327-337 1420-682X 72:2<327 2015 72 18