caa a22 4500 606177124 CHVBK 20210128100750.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1739-4 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1739-4 Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes [Elektronische Daten] [Ling Gu, Honglin Liu, Xi Gu, Christina Boots, Kelle Moley, Qiang Wang] Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As the epidemic of metabolic disorders continues, the associated medical co-morbidities, including the detrimental impact on reproduction, increase as well. Emerging evidence suggests that the effects of maternal nutrition on reproductive outcomes are likely to be mediated, at least in part, by oocyte metabolism. Well-balanced and timed energy metabolism is critical for optimal development of oocytes. To date, much of our understanding of oocyte metabolism comes from the effects of extrinsic nutrients on oocyte maturation. In contrast, intrinsic regulation of oocyte development by metabolic enzymes, intracellular mediators, and transport systems is less characterized. Specifically, decreased acid transport proteins levels, increased glucose/lipid content and elevated reactive oxygen species in oocytes have been implicated in meiotic defects, organelle dysfunction and epigenetic alteration. Therefore, metabolic disturbances in oocytes may contribute to the diminished reproductive potential experienced by women with metabolic disorders. In-depth research is needed to further explore the underlying mechanisms. This review also discusses several approaches for metabolic analysis. Metabolomic profiling of oocytes, the surrounding granulosa cells, and follicular fluid will uncover the metabolic networks regulating oocyte development, potentially leading to the identification of oocyte quality markers and prevention of reproductive disease and poor outcomes in offspring. Springer Basel, 2014 Germ cell nationallicence Glucose nationallicence Lipid nationallicence Amino acid nationallicence Biomarker nationallicence Gu Ling College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, 210095, Nanjing, Jiangsu, China aut Liu Honglin College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, 210095, Nanjing, Jiangsu, China aut Gu Xi Department of Obstetrics and Gynecology, Rudong Third Hospital, Nantong, China aut Boots Christina Washington University School of Medicine, St Louis, MO, USA aut Moley Kelle Washington University School of Medicine, St Louis, MO, USA aut Wang Qiang State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Rd, 210029, Nanjing, Jiangsu, China aut Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 251-271 1420-682X 72:2<251 2015 72 18 https://doi.org/10.1007/s00018-014-1739-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1739-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gu Ling College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, 210095, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Liu Honglin College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, 210095, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Gu Xi Department of Obstetrics and Gynecology, Rudong Third Hospital, Nantong, China aut NATIONALLICENCE 700 1- Boots Christina Washington University School of Medicine, St Louis, MO, USA aut NATIONALLICENCE 700 1- Moley Kelle Washington University School of Medicine, St Louis, MO, USA aut NATIONALLICENCE 700 1- Wang Qiang State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Rd, 210029, Nanjing, Jiangsu, China aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 251-271 1420-682X 72:2<251 2015 72 18