caa a22 4500 606177159 CHVBK 20210128100750.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1742-9 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1742-9 The mammalian Hippo pathway: regulation and function of YAP1 and TAZ [Elektronische Daten] [Manami Kodaka, Yutaka Hata] The Hippo pathway was originally identified as the signaling that controls organ size in Drosophila, with the core architecture conserved in mammals. In the mammalian Hippo pathway, mammalian Ste20-like kinases (MST1/2) and large tumor suppressor kinases (LATS1/2) regulate transcriptional co-activators, Yes-associated protein (YAP1) and Transcriptional co-activator with a PDZ-binding motif (TAZ). The Hippo pathway was initially thought to be quite straightforward; however, the identification of additional components has revealed its inherent complexity. Regulation of YAP1 and TAZ is not always dependent on MST1/2 and LATS1/2. MST1/2 and LATS1/2 play various YAP1/TAZ-independent roles, while YAP1 and TAZ cross-talk with other signaling pathways. In this review we focus on YAP1 and TAZ and discuss their regulation, function, and the consequences of their dysregulation. Springer Basel, 2014 Cancer nationallicence Stem cell nationallicence Cell differentiation nationallicence Development nationallicence Regeneration nationallicence Tumor suppressor nationallicence Kodaka Manami Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8519, Tokyo, Japan aut Hata Yutaka Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8519, Tokyo, Japan aut Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 285-306 1420-682X 72:2<285 2015 72 18 https://doi.org/10.1007/s00018-014-1742-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1742-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kodaka Manami Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8519, Tokyo, Japan aut NATIONALLICENCE 700 1- Hata Yutaka Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8519, Tokyo, Japan aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 285-306 1420-682X 72:2<285 2015 72 18