caa a22 4500 606177167 CHVBK 20210128100750.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1750-9 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1750-9 Chromogranin A: a paradoxical player in angiogenesis and vascular biology [Elektronische Daten] [Karen Helle, Angelo Corti] Half a century after the discovery of chromogranin A as a secreted product of the catecholamine storage granules in the bovine adrenal medulla, the physiological role for the circulating pool of this protein has been recently coined, namely as an important player in vascular homeostasis. While the circulating chromogranin A since 1984 has proved to be a significant and useful marker of a wide range of pathophysiological and pathological conditions involving the diffuse neuroendocrine system, this protein has now been assigned a physiological "raison d'etre” as a regulator in vascular homeostasis. Moreover, chromogranin A processing in response to tissue damage and blood coagulation provides the first indication of a difference in time frame of the regulation of angiogenesis evoked by the intact chromogranin A and its two major peptide products, vasostatin-1 and catestatin. The impact of these discoveries on vascular homeostasis, angiogenesis, cancer, tissue repair and cardio-regulation will be discussed. Springer Basel, 2014 ELISA assays nationallicence Endothelial barrier nationallicence Angiogenic switch nationallicence Cardiovascular regulation nationallicence Cancer nationallicence Proteolytic processing nationallicence Helle Karen Department of Biomedicine, University of Bergen, Haukelandsvei 1, 5009, Bergen, Norway aut Corti Angelo Division of Oncology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy aut Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 339-348 1420-682X 72:2<339 2015 72 18 https://doi.org/10.1007/s00018-014-1750-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1750-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Helle Karen Department of Biomedicine, University of Bergen, Haukelandsvei 1, 5009, Bergen, Norway aut NATIONALLICENCE 700 1- Corti Angelo Division of Oncology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 339-348 1420-682X 72:2<339 2015 72 18