caa a22 4500 606177191 CHVBK 20210128100751.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1741-x doi (NATIONALLICENCE)springer-10.1007/s00018-014-1741-x Immunogenicity of necrotic cell death [Elektronische Daten] [Jaba Gamrekelashvili, Tim Greten, Firouzeh Korangy] The mode of tumor cell death has significant effects on anti-tumor immunity. Although, previously it was thought that cell death is an inert effect, different investigators have clearly shown that dying tumors can attract, activate and mature professional antigen presenting cells and dendritic cells. In addition, others and we have shown that the type of tumor cell death not only controls the presence or absence of specific tumor antigens, but also can result in immunological responses ranging from immunosuppression to anti-tumor immunity. More importantly, it is possible to enhance anti-tumor immunity both in vitro and in vivo by targeting specific molecular mechanisms such as oligopeptidases and the proteasome. These studies not only extend our knowledge on basic immunological questions and the induction of anti-tumor immunity, but also have implications for all types of cancer treatments, in which rapid tumor cell death is induced. This review is a comprehensive summary of cell death and particularly necrosis and the pivotal role it plays in anti-tumor immunity. Springer Basel (outside the USA), 2014 Cell death nationallicence Peptidase nationallicence Immunogenic cell death nationallicence Cancer vaccine nationallicence CD8+ T cell nationallicence DAMP : Damage-associated molecular pattern molecules nationallicence PAMP : Pathogen-associated molecular pattern molecules nationallicence IFN : Interferon nationallicence HMGB1 : High mobility group box 1 protein nationallicence TNF : Tumor necrosis factor nationallicence TLR : Toll-like receptor nationallicence RIPK : Receptor-interacting protein kinase nationallicence APC : Antigen presenting cell nationallicence ICD : Immunogenic cell death nationallicence ER : Endoplasmic reticulum nationallicence ROS : Reactive oxygen species nationallicence CRT : Calreticulin nationallicence HSP : Heat shock protein nationallicence LPS : Lipopolysaccharide nationallicence RAGE : Receptor for advanced glycosylation end product nationallicence IL : Interleukin nationallicence RNP : Ribonucleoproteins nationallicence PRR : Pattern recognition receptor nationallicence DC : Dendritic cell nationallicence DRiP : Defective ribosomal product nationallicence OVA : Ovalbumin nationallicence LAP : Leuzin aminopeptidase nationallicence PSA : Puromycine-sensitive aminopeptidase nationallicence BH : Bleomycin hydrolase nationallicence TOP-1 : Thimet oligopeptidase 1 nationallicence TPPII : Tripeptidyl peptidase II nationallicence ERAP : ER aminopeptidase nationallicence ERAAP : ER aminopeptidase associated with antigen processing nationallicence DRibbles : DRiPs-containing blebs nationallicence DPP-3 : Dipeptidyl peptidase 3 nationallicence PEP : Prolyl endopeptidase nationallicence Ag : Antigen nationallicence Gamrekelashvili Jaba Department of Nephrology, Medizinische Hochschule Hannover, Hannover, Germany aut Greten Tim Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH/NCI/CCR Building 10 Rm 12N226, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Korangy Firouzeh Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH/NCI/CCR Building 10 Rm 12N226, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 273-283 1420-682X 72:2<273 2015 72 18 https://doi.org/10.1007/s00018-014-1741-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1741-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gamrekelashvili Jaba Department of Nephrology, Medizinische Hochschule Hannover, Hannover, Germany aut NATIONALLICENCE 700 1- Greten Tim Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH/NCI/CCR Building 10 Rm 12N226, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Korangy Firouzeh Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH/NCI/CCR Building 10 Rm 12N226, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/2(2015-01-01), 273-283 1420-682X 72:2<273 2015 72 18