caa a22 4500 606177280 CHVBK 20210128100751.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00018-015-1984-1 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1984-1 Emerging roles of nucleolar and ribosomal proteins in cancer, development, and aging [Elektronische Daten] [Hitomi Takada, Akira Kurisaki] Changes in nucleolar morphology and function are tightly associated with cellular activity, such as growth, proliferation, and cell cycle progression. Historically, these relationships have been extensively examined in cancer cells, which frequently exhibit large nucleoli and increased ribosome biogenesis. Recent findings indicate that alteration of nucleolar activity is a key regulator of development and aging. In this review, we have provided evidences that the nucleolus is not just a housekeeping factor but is actively involved in the regulation of cell proliferation, differentiation, and senescence both in vitro and in vivo. In addition, we have discussed how alteration of nucleolar function and nucleolar proteins induces specific physiological effects rather than widespread effects. Springer Basel, 2015 Nucleolus nationallicence Ribosome biogenesis nationallicence Stem cells nationallicence Differentiation nationallicence Longevity nationallicence ES cells : Embryonic stem cells nationallicence pre-rRNA : Precursor ribosomal RNA nationallicence Pol I : RNApolymerase I nationallicence rDNA : Ribosomal DNA nationallicence snoRNPs : Small nucleolar ribonucleoprotein particles nationallicence TIF-IA : Transcription initiation factor IA nationallicence UBF : Upstream binding factor nationallicence Takada Hitomi Stem Cell Engineering Research Group, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1, Higashi, 305-8562, Tsukuba, Ibaraki, Japan aut Kurisaki Akira Stem Cell Engineering Research Group, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1, Higashi, 305-8562, Tsukuba, Ibaraki, Japan aut Cellular and Molecular Life Sciences Springer Basel 72/21(2015-11-01), 4015-4025 1420-682X 72:21<4015 2015 72 18 https://doi.org/10.1007/s00018-015-1984-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1984-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takada Hitomi Stem Cell Engineering Research Group, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1, Higashi, 305-8562, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Kurisaki Akira Stem Cell Engineering Research Group, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1, Higashi, 305-8562, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/21(2015-11-01), 4015-4025 1420-682X 72:21<4015 2015 72 18