caa a22 4500 606177302 CHVBK 20210128100751.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00018-015-1989-9 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1989-9 p53 regulates cytoskeleton remodeling to suppress tumor progression [Elektronische Daten] [Keigo Araki, Takahiro Ebata, Alvin Guo, Kei Tobiume, Steven Wolf, Keiko Kawauchi] Cancer cells possess unique characteristics such as invasiveness, the ability to undergo epithelial-mesenchymal transition, and an inherent stemness. Cell morphology is altered during these processes and this is highly dependent on actin cytoskeleton remodeling. Regulation of the actin cytoskeleton is, therefore, important for determination of cell fate. Mutations within the TP53 (tumor suppressor p53) gene leading to loss or gain of function (GOF) of the protein are often observed in aggressive cancer cells. Here, we highlight the roles of p53 and its GOF mutants in cancer cell invasion from the perspective of the actin cytoskeleton; in particular its reorganization and regulation by cell adhesion molecules such as integrins and cadherins. We emphasize the multiple functions of p53 in the regulation of actin cytoskeleton remodeling in response to the extracellular microenvironment, and oncogene activation. Such an approach provides a new perspective in the consideration of novel targets for anti-cancer therapy. Springer Basel, 2015 p53 nationallicence p63 nationallicence Rho GTPases nationallicence Focal adhesion proteins nationallicence Mechanotransduction nationallicence ECM degradation nationallicence Contractile forces nationallicence Metastasis nationallicence Araki Keigo Frontiers of Innovative Research in Science and Technology, Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, 650-0047, Kobe, Hyogo, Japan aut Ebata Takahiro Frontiers of Innovative Research in Science and Technology, Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, 650-0047, Kobe, Hyogo, Japan aut Guo Alvin Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, 8 College Road, 169857, Singapore, Singapore aut Tobiume Kei Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan aut Wolf Steven Mechanobiology Institute, National University of Singapore, T-Lab, 5A Engineering Drive 1, 117411, Singapore, Singapore aut Kawauchi Keiko Frontiers of Innovative Research in Science and Technology, Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, 650-0047, Kobe, Hyogo, Japan aut Cellular and Molecular Life Sciences Springer Basel 72/21(2015-11-01), 4077-4094 1420-682X 72:21<4077 2015 72 18 https://doi.org/10.1007/s00018-015-1989-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1989-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Araki Keigo Frontiers of Innovative Research in Science and Technology, Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, 650-0047, Kobe, Hyogo, Japan aut NATIONALLICENCE 700 1- Ebata Takahiro Frontiers of Innovative Research in Science and Technology, Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, 650-0047, Kobe, Hyogo, Japan aut NATIONALLICENCE 700 1- Guo Alvin Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, 8 College Road, 169857, Singapore, Singapore aut NATIONALLICENCE 700 1- Tobiume Kei Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Hiroshima, Japan aut NATIONALLICENCE 700 1- Wolf Steven Mechanobiology Institute, National University of Singapore, T-Lab, 5A Engineering Drive 1, 117411, Singapore, Singapore aut NATIONALLICENCE 700 1- Kawauchi Keiko Frontiers of Innovative Research in Science and Technology, Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, 650-0047, Kobe, Hyogo, Japan aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/21(2015-11-01), 4077-4094 1420-682X 72:21<4077 2015 72 18