caa a22 4500 606177310 CHVBK 20210128100751.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00018-015-2028-6 doi (NATIONALLICENCE)springer-10.1007/s00018-015-2028-6 Canonical and noncanonical Wnt signaling in neural stem/progenitor cells [Elektronische Daten] [Nora Bengoa-Vergniory, Robert Kypta] The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the development of a large part of the mouse brain over 25years ago. We have since learned that Wnt family secreted glycolipoproteins, of which there are nineteen, which activate a diverse network of signals that are particularly important during embryonic development and tissue regeneration. Wnt signals in the developing and adult brain can drive neural stem cell self-renewal, expansion, asymmetric cell division, maturation and differentiation. The molecular events taking place after a Wnt binds to its cell-surface receptors are complex and, at times, controversial. A deeper understanding of these events is anticipated to lead to improvements in the treatment of neurodegenerative diseases and stem cell-based replacement therapies. Here, we review the roles played by Wnts in neural stem cells in the developing mouse brain, at neurogenic sites of the adult mouse and in neural stem cell culture models. Springer Basel, 2015 Wnt signaling nationallicence Neural stem cells nationallicence Beta-catenin nationallicence AP-1 family transcription factors nationallicence Bengoa-Vergniory Nora Cell Biology and Stem Cells Unit, CIC bioGUNE, Bilbao, Spain aut Kypta Robert Cell Biology and Stem Cells Unit, CIC bioGUNE, Bilbao, Spain aut Cellular and Molecular Life Sciences Springer Basel 72/21(2015-11-01), 4157-4172 1420-682X 72:21<4157 2015 72 18 https://doi.org/10.1007/s00018-015-2028-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2028-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bengoa-Vergniory Nora Cell Biology and Stem Cells Unit, CIC bioGUNE, Bilbao, Spain aut NATIONALLICENCE 700 1- Kypta Robert Cell Biology and Stem Cells Unit, CIC bioGUNE, Bilbao, Spain aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/21(2015-11-01), 4157-4172 1420-682X 72:21<4157 2015 72 18