caa a22 4500 606177353 CHVBK 20210128100751.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00018-015-1880-8 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1880-8 Structure and function insights into the NuRD chromatin remodeling complex [Elektronische Daten] [Morgan Torchy, Ali Hamiche, Bruno Klaholz] Transcription regulation through chromatin compaction and decompaction is regulated through various chromatin-remodeling complexes such as nucleosome remodeling and histone deacetylation (NuRD) complex. NuRD is a 1MDa multi-subunit protein complex which comprises many different subunits, among which histone deacetylases HDAC1/2, ATP-dependent remodeling enzymes CHD3/4, histone chaperones RbAp46/48, CpG-binding proteins MBD2/3, the GATAD2a (p66α) and/or GATAD2b (p66β) and specific DNA-binding proteins MTA1/2/3. Here, we review the currently known crystal and NMR structures of these subunits, the functional data and their relevance for biomedical research considering the implication of NuRD subunits in cancer and various other diseases. The complexity of this macromolecular assembly, and its poorly understood mode of interaction with the nucleosome, the repeating unit of chromatin, illustrate that this complex is a major challenge for structure-function relationship studies which will be tackled best by an integrated biology approach. Springer Basel, 2015 NuRD nationallicence Remodeling nationallicence Deacetylase nationallicence Chromatin nationallicence Nucleosome nationallicence Structural biology nationallicence Torchy Morgan Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 1 rue Laurent Fries, Illkirch, France aut Hamiche Ali Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 1 rue Laurent Fries, Illkirch, France aut Klaholz Bruno Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 1 rue Laurent Fries, Illkirch, France aut Cellular and Molecular Life Sciences Springer Basel 72/13(2015-07-01), 2491-2507 1420-682X 72:13<2491 2015 72 18 https://doi.org/10.1007/s00018-015-1880-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1880-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Torchy Morgan Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 1 rue Laurent Fries, Illkirch, France aut NATIONALLICENCE 700 1- Hamiche Ali Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 1 rue Laurent Fries, Illkirch, France aut NATIONALLICENCE 700 1- Klaholz Bruno Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 1 rue Laurent Fries, Illkirch, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/13(2015-07-01), 2491-2507 1420-682X 72:13<2491 2015 72 18