caa a22 4500 606177388 CHVBK 20210128100751.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00018-015-1835-0 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1835-0 Nolz Jeffrey Department of Molecular Microbiology and Immunology, Oregon Health and Science University, 6516 Richard Jones Hall, 3181 SW Sam Jackson Park Road, Mail Code: L220, 97239, Portland, OR, USA aut Molecular mechanisms of CD8+ T cell trafficking and localization [Elektronische Daten] [Jeffrey Nolz] Cytotoxic CD8+ T cells are potent mediators of host protection against disease due to their ability to directly kill cells infected with intracellular pathogens and produce inflammatory cytokines at the site of infection. To fully achieve this objective, naïve CD8+ T cells must be able to survey the entire body for the presence of foreign or "non-self” antigen that is delivered to draining lymph nodes following infection or tissue injury. Once activated, CD8+ T cells undergo many rounds of cell division, acquire effector functions, and are no longer restricted to the circulation and lymphoid compartments like their naïve counterparts, but rather are drawn to inflamed tissues to combat infection. As CD8+ T cells transition from naïve to effector to memory populations, this is accompanied by dynamic changes in the expression of adhesion molecules and chemokine receptors that ultimately dictate their localization in vivo. Thus, an understanding of the molecular mechanisms regulating CD8+ T cell trafficking and localization is critical for vaccine design, control of infectious diseases, treatment of autoimmune disorders, and cancer immunotherapy. Springer Basel, 2015 CD8+ T cells nationallicence Selectins nationallicence Integrins nationallicence Chemokines nationallicence Vaccines nationallicence Trafficking nationallicence Cellular and Molecular Life Sciences Springer Basel 72/13(2015-07-01), 2461-2473 1420-682X 72:13<2461 2015 72 18 https://doi.org/10.1007/s00018-015-1835-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1835-0 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Nolz Jeffrey Department of Molecular Microbiology and Immunology, Oregon Health and Science University, 6516 Richard Jones Hall, 3181 SW Sam Jackson Park Road, Mail Code: L220, 97239, Portland, OR, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/13(2015-07-01), 2461-2473 1420-682X 72:13<2461 2015 72 18