caa a22 4500 60617740X CHVBK 20210128100752.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00018-015-1885-3 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1885-3 Blood flow mechanics in cardiovascular development [Elektronische Daten] [Francesco Boselli, Jonathan Freund, Julien Vermot] Hemodynamic forces are fundamental to development. Indeed, much of cardiovascular morphogenesis reflects a two-way interaction between mechanical forces and the gene network activated in endothelial cells via mechanotransduction feedback loops. As these interactions are becoming better understood in different model organisms, it is possible to identify common mechanogenetic rules, which are strikingly conserved and shared in many tissues and species. Here, we discuss recent findings showing how hemodynamic forces potentially modulate cardiovascular development as well as the underlying fluid and tissue mechanics, with special attention given to the flow characteristics that are unique to the small scales of embryos. The Author(s), 2015 Angiogenesis nationallicence Fluid mechanics nationallicence Valvulopathie nationallicence Atherosclerosis nationallicence Klf2 nationallicence Biomechanics nationallicence Cardiomyopathy nationallicence Boselli Francesco Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France aut Freund Jonathan Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 61801, Urbana, IL, USA aut Vermot Julien Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France aut Cellular and Molecular Life Sciences Springer Basel 72/13(2015-07-01), 2545-2559 1420-682X 72:13<2545 2015 72 18 https://doi.org/10.1007/s00018-015-1885-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1885-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boselli Francesco Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France aut NATIONALLICENCE 700 1- Freund Jonathan Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 61801, Urbana, IL, USA aut NATIONALLICENCE 700 1- Vermot Julien Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/13(2015-07-01), 2545-2559 1420-682X 72:13<2545 2015 72 18