caa a22 4500 606177434 CHVBK 20210128100752.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00018-015-1876-4 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1876-4 Inflammation: a culprit for vascular calcification in atherosclerosis and diabetes [Elektronische Daten] [L. Bessueille, D. Magne] It is today acknowledged that aging is associated with a low-grade chronic inflammatory status, and that inflammation exacerbates age-related diseases such as osteoporosis, Alzheimer's disease, atherosclerosis and type 2 diabetes mellitus (T2DM). Vascular calcification is a complication that also occurs during aging, in particular in association with atherosclerosis and T2DM. Recent studies provided compelling evidence that vascular calcification is associated with inflammatory status and is enhanced by inflammatory cytokines. In the present review, we propose on one hand to highlight the most important and recent findings on the cellular and molecular mechanisms of vascular inflammation in atherosclerosis and T2DM. On the other hand, we will present the effects of inflammatory mediators on the trans-differentiation of vascular smooth muscle cell and on the deposition of crystals. Since vascular calcification significantly impacts morbidity and mortality in affected individuals, a better understanding of its induction and development will pave the way to develop new therapeutic strategies. Springer Basel, 2015 Vascular smooth muscle cells nationallicence Chondrocytes nationallicence TNF-α nationallicence IL-1β nationallicence Inflammasome nationallicence ANKH : Ankylosis protein homolog nationallicence BMP : Bone morphogenetic protein nationallicence CAC : Coronary artery calcification nationallicence CKD : Chronic kidney disease nationallicence CRP : C-reactive protein nationallicence ECM : Extracellular matrix nationallicence ENPP1 : Ectonucleotide pyrophosphatase phosphodiesterase 1 nationallicence FDG : Fluorodeoxyglucose nationallicence GACI : Generalized arterial calcification in infancy nationallicence HIF : Hypoxia inducible factor nationallicence HPGS : Hutchinson-Gilford progeria syndrome nationallicence IFN : Interferon nationallicence IL-1Ra : Interleukin-1 receptor antagonist nationallicence MGP : Matrix Gla protein nationallicence MMP : Matrix metalloprotease nationallicence MVs : Matrix vesicles nationallicence NLRP3 : NOD-like receptor family, pyrin domain containing 3 nationallicence PET : Positron emission tomography nationallicence PPi : Inorganic pyrophosphate nationallicence T2DM : Type 2 diabetes mellitus nationallicence VSMCs : Vascular smooth muscle cells nationallicence TNAP : Tissue nonspecific alkaline phosphatase nationallicence TNF : Tumor necrosis factor nationallicence Bessueille L. University of Lyon, ICBMS UMR CNRS 5246, Bâtiment Raulin, 43 Bd du 11 novembre 1918, 69622, Villeurbanne Cedex, France aut Magne D. University of Lyon, ICBMS UMR CNRS 5246, Bâtiment Raulin, 43 Bd du 11 novembre 1918, 69622, Villeurbanne Cedex, France aut Cellular and Molecular Life Sciences Springer Basel 72/13(2015-07-01), 2475-2489 1420-682X 72:13<2475 2015 72 18 https://doi.org/10.1007/s00018-015-1876-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1876-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bessueille L. University of Lyon, ICBMS UMR CNRS 5246, Bâtiment Raulin, 43 Bd du 11 novembre 1918, 69622, Villeurbanne Cedex, France aut NATIONALLICENCE 700 1- Magne D. University of Lyon, ICBMS UMR CNRS 5246, Bâtiment Raulin, 43 Bd du 11 novembre 1918, 69622, Villeurbanne Cedex, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/13(2015-07-01), 2475-2489 1420-682X 72:13<2475 2015 72 18