caa a22 4500 606177450 CHVBK 20210128100752.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00018-015-1855-9 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1855-9 On the move: endocytic trafficking in cell migration [Elektronische Daten] [Tanja Maritzen, Hannah Schachtner, Daniel Legler] Directed cell migration is a fundamental process underlying diverse physiological and pathophysiological phenomena ranging from wound healing and induction of immune responses to cancer metastasis. Recent advances reveal that endocytic trafficking contributes to cell migration in multiple ways. (1) At the level of chemokines and chemokine receptors: internalization of chemokines by scavenger receptors is essential for shaping chemotactic gradients in tissue, whereas endocytosis of chemokine receptors and their subsequent recycling is key for maintaining a high responsiveness of migrating cells. (2) At the level of integrin trafficking and focal adhesion dynamics: endosomal pathways do not only modulate adhesion by delivering integrins to their site of action, but also by supplying factors for focal adhesion disassembly. (3) At the level of extracellular matrix reorganization: endosomal transport contributes to tumor cell migration not only by targeting integrins to invadosomes but also by delivering membrane type 1 matrix metalloprotease to the leading edge facilitating proteolysis-dependent chemotaxis. Consequently, numerous endocytic and endosomal factors have been shown to modulate cell migration. In fact key modulators of endocytic trafficking turn out to be also key regulators of cell migration. This review will highlight the recent progress in unraveling the contribution of cellular trafficking pathways to cell migration. Springer Basel, 2015 Endocytosis nationallicence Cellular motility nationallicence Clathrin nationallicence Chemotaxis nationallicence Signal transduction nationallicence Vesicular transport nationallicence Maritzen Tanja Leibniz Institute for Molecular Pharmacology, Robert-Roessle-Str. 10, 13125, Berlin, Germany aut Schachtner Hannah Leibniz Institute for Molecular Pharmacology, Robert-Roessle-Str. 10, 13125, Berlin, Germany aut Legler Daniel Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Unterseestrasse 47, 8280, Kreuzlingen, Switzerland aut Cellular and Molecular Life Sciences Springer Basel 72/11(2015-06-01), 2119-2134 1420-682X 72:11<2119 2015 72 18 https://doi.org/10.1007/s00018-015-1855-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1855-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maritzen Tanja Leibniz Institute for Molecular Pharmacology, Robert-Roessle-Str. 10, 13125, Berlin, Germany aut NATIONALLICENCE 700 1- Schachtner Hannah Leibniz Institute for Molecular Pharmacology, Robert-Roessle-Str. 10, 13125, Berlin, Germany aut NATIONALLICENCE 700 1- Legler Daniel Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Unterseestrasse 47, 8280, Kreuzlingen, Switzerland aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/11(2015-06-01), 2119-2134 1420-682X 72:11<2119 2015 72 18