caa a22 4500 606177515 CHVBK 20210128100752.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00018-015-1859-5 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1859-5 Orchestral maneuvers at the damaged sites in nucleotide excision repair [Elektronische Daten] [Sergey Alekseev, Frédéric Coin] To safeguard the genome from the accumulation of deleterious effects arising from DNA lesions, cells developed several DNA repair mechanisms that remove specific types of damage from the genome. Among them, Nucleotide Excision Repair (NER) is unique in its ability to remove a very broad spectrum of lesions, the most important of which include UV-induced damage, bulky chemical adducts and some forms of oxidative damage. Two sub-pathways exist in NER; Transcription-Coupled Repair (TC-NER) removes lesion localized exclusively in transcribed genes while Global Genome Repair (GG-NER) removes lesions elsewhere. In TC- or GG-NER, more than 30 proteins detect, open, incise and resynthesize DNA. Intriguingly, half of them are involved in the detection of DNA damage, implying that this is a crucial repair step requiring a high level of regulation. We review here the complex damage recognition step of GG-NER with a focus on post-translational modifications that help the comings and goings of several protein complexes on the same short damaged DNA locus. Springer Basel, 2015 DDB2 nationallicence XPC nationallicence XPA nationallicence TFIIH nationallicence Alekseev Sergey Department of Functional Genomics and Cancer, IGBMC, Equipe Labellisée Ligue 2014, CNRS/INSERM/University of Strasbourg, BP 163, 67404, Illkirch Cedex, C. U. Strasbourg, France aut Coin Frédéric Department of Functional Genomics and Cancer, IGBMC, Equipe Labellisée Ligue 2014, CNRS/INSERM/University of Strasbourg, BP 163, 67404, Illkirch Cedex, C. U. Strasbourg, France aut Cellular and Molecular Life Sciences Springer Basel 72/11(2015-06-01), 2177-2186 1420-682X 72:11<2177 2015 72 18 https://doi.org/10.1007/s00018-015-1859-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1859-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alekseev Sergey Department of Functional Genomics and Cancer, IGBMC, Equipe Labellisée Ligue 2014, CNRS/INSERM/University of Strasbourg, BP 163, 67404, Illkirch Cedex, C. U. Strasbourg, France aut NATIONALLICENCE 700 1- Coin Frédéric Department of Functional Genomics and Cancer, IGBMC, Equipe Labellisée Ligue 2014, CNRS/INSERM/University of Strasbourg, BP 163, 67404, Illkirch Cedex, C. U. Strasbourg, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/11(2015-06-01), 2177-2186 1420-682X 72:11<2177 2015 72 18