caa a22 4500 606177531 CHVBK 20210128100752.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00018-015-1853-y doi (NATIONALLICENCE)springer-10.1007/s00018-015-1853-y An updated review of mechanotransduction in skin disorders: transcriptional regulators, ion channels, and microRNAs [Elektronische Daten] [Jing Wang, Yifan Zhang, Ning Zhang, Chuandong Wang, Tanja Herrler, Qingfeng Li] Introduction: The skin is constantly exposed and responds to a wide range of biomechanical cues. The mechanobiology of skin has already been known and applied by clinicians long before the fundamental molecular mechanisms of mechanotransduction are elucidated. Materials and methods: Despite increasing knowledge on the mediators of biomechanical signaling such as mitogen-associated protein kinases, Rho GTPases or FAK-ERK pathways, the key elements of mechano-responses transcription factors, and mechano-sensors remain unclear. Recently, canonical biochemical components of Hippo and Wnt signaling pathway YAP and β-catenin were found to exhibit undefined mechanical sensitivity. Mechanical forces were identified to be the dominant regulators of YAP/TAZ activity in a multicellular context. Furthermore, different voltage or ligand sensitive ion channels in the cell membrane exhibited their mechanical sensitivityas mechano-sensors. Additionally, a large number of microRNAs have been confirmed to regulate cellular behavior and contribute to various skin disorders under mechanical stimuli. Mechanosensitive (MS) microRNAs could not only be activated by distinct mechanical force pattern, but also responsively target MS sensors such as e-cadherin and cytoskeleton constituent RhoA. Conclusion: Thus, a comprehensive understanding of this regulatory network of cutaneous mechanotransduction will facilitate the development of novel approaches to wound healing, hypertrophic scar formation, skin regeneration, and the progression or initiation of skin diseases. Springer Basel, 2015 TRP nationallicence Piezo nationallicence Wound healing nationallicence Hypertrophic scar nationallicence Fibrosis nationallicence Scleroderma nationallicence YAP : Yes-associated protein nationallicence AP-1 : Activator protein 1 nationallicence ECM : Extracellular matrix nationallicence MS : Mechanosensitive nationallicence MAPKs : Mitogen-associated protein kinases nationallicence FAK : Focal adhesion kinase nationallicence ERK : Extracellular regulated protein kinases nationallicence PI3K : Phosphoinositol-3-kinase nationallicence HF : Hair follicles nationallicence IFE : Interfollicular epidermal nationallicence MSCs : Mesenchymal stem cells nationallicence GPCRs : G-Protein-coupled receptors nationallicence CaSR : Calcium-sensing receptor nationallicence TRP : Transient receptor potential nationallicence ECs : Endothelial cells nationallicence Cx : Connexin nationallicence Wang Jing Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China aut Zhang Yifan Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China aut Zhang Ning The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Shanghai Jiao Tong University School of Medicine, Shanghai, China aut Wang Chuandong The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Shanghai Jiao Tong University School of Medicine, Shanghai, China aut Herrler Tanja Hand, Plastic, and Aesthetic Surgery, Department of General, Trauma, Hand, and Plastic Surgery, University of Munich, Munich, Germany aut Li Qingfeng Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China aut Cellular and Molecular Life Sciences Springer Basel 72/11(2015-06-01), 2091-2106 1420-682X 72:11<2091 2015 72 18 https://doi.org/10.1007/s00018-015-1853-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1853-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Jing Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China aut NATIONALLICENCE 700 1- Zhang Yifan Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China aut NATIONALLICENCE 700 1- Zhang Ning The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Shanghai Jiao Tong University School of Medicine, Shanghai, China aut NATIONALLICENCE 700 1- Wang Chuandong The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Shanghai Jiao Tong University School of Medicine, Shanghai, China aut NATIONALLICENCE 700 1- Herrler Tanja Hand, Plastic, and Aesthetic Surgery, Department of General, Trauma, Hand, and Plastic Surgery, University of Munich, Munich, Germany aut NATIONALLICENCE 700 1- Li Qingfeng Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/11(2015-06-01), 2091-2106 1420-682X 72:11<2091 2015 72 18